Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis

Shahab Uddin; Azhar R. Hussain; Omar S. Khan; Khawla S. Al-Kuraya

doi:10.1007/s13277-013-1166-4

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis

Shahab Uddin, Azhar R. Hussain, Omar S. Khan, Khawla S. Al-Kuraya

Research output: Contribution to journal › Review article › peer-review

19 Citations (Scopus)

Abstract

Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor's roles in the pathogenesis of colonogenic cancer has been described.

Original language	English
Pages (from-to)	871-879
Number of pages	9
Journal	Tumor Biology
Volume	35
Issue number	2
DOIs	https://doi.org/10.1007/s13277-013-1166-4
Publication status	Published - Feb 2014
Externally published	Yes

Keywords

Colorectal cancer
Leptin
Ob-R
PI3-kinase/AKT pathway

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13277-013-1166-4

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title = "Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis",

abstract = "Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor's roles in the pathogenesis of colonogenic cancer has been described.",

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T1 - Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis

AU - Uddin, Shahab

AU - Hussain, Azhar R.

AU - Khan, Omar S.

AU - Al-Kuraya, Khawla S.

PY - 2014/2

Y1 - 2014/2

N2 - Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor's roles in the pathogenesis of colonogenic cancer has been described.

AB - Leptin is a multifunctional adipose-derived cytokine that plays a critical role in bodyweight homeostasis and energy balance. Plasma level of leptin is an indicator of the amount of energy stored in adipose tissues. Recently, leptin and leptin receptor dysregulation have been reported in a variety of malignant cells including colorectal cancers (CRCs). There are growing evidence that leptin may be the link between obesity and CRC carcinogenesis. Leptin influence the growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT, and/or MAP kinases. In this review, current understanding of leptin and its receptor's roles in the pathogenesis of colonogenic cancer has been described.

KW - Colorectal cancer

KW - Leptin

KW - Ob-R

KW - PI3-kinase/AKT pathway

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DO - 10.1007/s13277-013-1166-4

M3 - Review article

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SN - 1010-4283

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SP - 871

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JF - Tumor Biology

IS - 2

ER -

Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis

Abstract

Keywords

UN SDGs

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