Abstract
Recent advancement in nanomedicine has provided a diverse array of applications for modulating stem cell behavior and fate for their therapeutic applications. Stem cells based tissue regeneration faces several challenges including inability of the cells to proliferate and differentiate in response to mechanical and chemical inducers, as well as inefficient and insufficient production of factors that are essential for stem cell growth and differentiation. The field of nanotechnology provides unique nanomaterials with significant clinical applications in the area of regenerative medicine. This chapter highlights the link between nanomedicine and tissue engineering, reviewing current literatures on the interactions between metallic nanoparticles (NPs) and stem cells, effects of NPs on stem cell differentiation into different lineages, and their potential therapeutic applications. In addition, the plausible mechanisms through which NPs could regulate the spatiotemporal release and kinetics of growth/differentiation factors, enhancing stem cell differentiation, and improving culture conditions for in vitro and in vivo tissue regeneration are also been narrated here. Understanding the mechanism of interactions between NPs and stem cells will certainly provide significant insight into their clinical applications in regenerative medicine.
| Original language | English (UK) |
|---|---|
| Title of host publication | Metal Nanoparticles for Drug Delivery and Diagnostic Applications |
| Publisher | Elsevier Inc. |
| Pages | 99-118 |
| Number of pages | 20 |
| ISBN (Print) | 9780128169605 |
| DOIs | |
| Publication status | Published - 22 Oct 2019 |
| Externally published | Yes |
Keywords
- Chondrogenesis
- Gene therapy
- Nanoparticles
- Osteogenesis
- Regenerative medicine
- Stem cells