TY - JOUR
T1 - Role of interferon gamma release assay in the diagnosis and management of Mycobacterium tuberculosis-associated uveitis
T2 - A review
AU - Rahman, Samra
AU - Irfan, Muhammad
AU - Rehman Siddiqui, M. A.
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2021/5/12
Y1 - 2021/5/12
N2 - Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: â € interferon-gamma release assay', â € QuantiFERON', â € T-SPOT.TB', â € TB uveitis', â € serpiginous like choroiditis', â € tuberculoma', â € TB vasculitis', â € TB panuveitis' and â € ocular tuberculosis'. Data from 58 relevant studies were collated. The review is focused on currently marketed versions of IGRA tests: QuantiFERON-TB Gold In-Tube assay, QuantiFERON-TB Gold Plus assay (QFT-Plus) and T-SPOT.TB. We found limited evidence regarding the diagnostic utility of IGRA in patients with uveitis. No study was identified evaluating the newer QFT test-the QFT-Plus-in patients with uveitis. Similarly, there is lack of data directly comparing QFT-Plus with T-SPOT.TB specifically for the diagnosis of TB uveitis.
AB - Tuberculosis (TB)-associated uveitis is a common cause of infectious uveitis in the developing world. Diagnosis of TB uveitis remains a challenge. The role of interferon gamma release assays (IGRAs) is uncertain. Herein we summarise the available literature on the utility of IGRAs in the diagnosis and management of TB uveitis. We searched PubMed database from 1 August 2010 to 31 July 2020 using the following keywords alone and in combination: â € interferon-gamma release assay', â € QuantiFERON', â € T-SPOT.TB', â € TB uveitis', â € serpiginous like choroiditis', â € tuberculoma', â € TB vasculitis', â € TB panuveitis' and â € ocular tuberculosis'. Data from 58 relevant studies were collated. The review is focused on currently marketed versions of IGRA tests: QuantiFERON-TB Gold In-Tube assay, QuantiFERON-TB Gold Plus assay (QFT-Plus) and T-SPOT.TB. We found limited evidence regarding the diagnostic utility of IGRA in patients with uveitis. No study was identified evaluating the newer QFT test-the QFT-Plus-in patients with uveitis. Similarly, there is lack of data directly comparing QFT-Plus with T-SPOT.TB specifically for the diagnosis of TB uveitis.
KW - diagnostic tests/investigation
KW - infection
KW - inflammation
UR - http://www.scopus.com/inward/record.url?scp=85105853783&partnerID=8YFLogxK
U2 - 10.1136/bmjophth-2020-000663
DO - 10.1136/bmjophth-2020-000663
M3 - Review article
AN - SCOPUS:85105853783
SN - 2397-3269
VL - 6
JO - BMJ Open Ophthalmology
JF - BMJ Open Ophthalmology
IS - 1
M1 - e000663
ER -
