Role of leptin and its receptors in the pathogenesis of thyroid cancer

Shahabuddin; Azhar Hussain; Abdul K Siraj; Omar S Khan; Prashant P Bavi; Khawla S Al-Kuraya

Role of leptin and its receptors in the pathogenesis of thyroid cancer

Shahabuddin
, Azhar Hussain
, Abdul K Siraj
, Omar S Khan
, Prashant P Bavi
, Khawla S Al-Kuraya

Department of Biological & Biomedical Sciences, Medical College, Pakistan

Research output: Contribution to journal › Article

Abstract

Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.

Original language	Undefined/Unknown
Journal	International Journal of Clinical and Experimental Pathology
Publication status	Published - 1 Jan 2011

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Cite this

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title = "Role of leptin and its receptors in the pathogenesis of thyroid cancer",

abstract = "Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.",

author = "Shahabuddin and Azhar Hussain and Siraj, \{Abdul K\} and Khan, \{Omar S\} and Bavi, \{Prashant P\} and Al-Kuraya, \{Khawla S\}",

year = "2011",

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day = "1",

language = "Undefined/Unknown",

journal = "International Journal of Clinical and Experimental Pathology",

issn = "1936-2625",

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T1 - Role of leptin and its receptors in the pathogenesis of thyroid cancer

AU - Shahabuddin,

AU - Hussain, Azhar

AU - Siraj, Abdul K

AU - Khan, Omar S

AU - Bavi, Prashant P

AU - Al-Kuraya, Khawla S

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.

AB - Leptin is a multifunctional adipose-derived cytokines that play a critical role in bodyweight homeostasis and energy balance. Recently, leptin and leptin receptor dysreulation have been reported in variety of malignant cells including thyroid. Leptin modulates growth and proliferation of cancer cells via activation of various growth and survival signaling pathways including JAK/STAT, PI3-kinase/AKT and/or Map kinases. In this review, current understanding of leptin's role in the pathogenesis of thyroid cancer has been described.

M3 - Article

SN - 1936-2625

JO - International Journal of Clinical and Experimental Pathology

JF - International Journal of Clinical and Experimental Pathology

ER -