Role of microRNAs in non-functioning pituitary adenoma

Mehak Rajani, Yumna Mirza, Rohan Advani, Syed Muhammad Adnan Ali, Syed Ather Enam

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)


Non-functioning pituitary adenomas account for 30% of anterior pituitary tumours. Based on their inability to secrete hormones, these are often diagnosed incidentally or due to pressure symptoms. Understanding the pathogenesis of these adenomas can provide insight into factors leading to its progression and serving as biomarkers for early recognition. A literature search was performed in the current narrative review for articles published in PubMed for the last 10 years till January 2020 on micro-ribonucleic acid involved in the pathogenesis of non-functioning pituitary adenomas. Of the 478 articles found, 21(4.4%) were filtered. In total, 106 micro-ribonucleic acids were identified, 25(23.5%) of which appeared in more than one study. Among them, 7(28%)were up-regulated, 11(44%) down-regulated, and 7(28%) were either up- or down-regulated. Micro-ribonucleic acids allow the screening, diagnosis and treatment of diseases in a relatively easy and inexpensive manner. This can revolutionise tumour management in the years ahead, especially in resource-constrained low- and middle-income countries.

Original languageEnglish
Pages (from-to)126-133
Number of pages8
JournalJournal of the Pakistan Medical Association
Issue number1
Publication statusPublished - Jan 2022


  • Cell signalling pathways
  • Non-functioning pituitary adenoma
  • Pathogenesis
  • Pituitary adenoma
  • Target genes
  • microRNA


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