Role of oxidative stress in the pathogenesis of preeclampsia

Imran A. Siddiqui, Anila Jaleel, Waleed Tamimi, Hanan M.F. Al Kadri

Research output: Contribution to journalReview articlepeer-review

98 Citations (Scopus)


Hypertensive disorders of pregnancy are associated with an increased risk of maternal and fetal morbidity and mortality. The cause and the pathogenesis of the pregnancy-induced syndrome, preeclampsia, is still poorly understood. Published evidence of altered biomarkers for the endothelial dysfunction suggests that the initiating event in preeclampsia is the reduced placental perfusion, which leads to widespread dysfunction of the maternal vascular endothelium. This review focuses on the role of free radicals in generating the oxidative stress taking antioxidants into consideration which tend to overcome it as well as the role of placenta in preeclamptic pregnancy.

Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalArchives of Gynecology and Obstetrics
Issue number5
Publication statusPublished - Nov 2010
Externally publishedYes


  • Antioxidants
  • Endothelial dysfunction
  • Oxidative stress
  • Preeclampsia


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