Role of stereotactic radiosurgery in the treatment of acromegaly

Komal Naeem, Aneela Darbar, Muhammad Shahzad Shamim

Research output: Contribution to journalArticlepeer-review


Acromegaly is a rare, indolent disease due to overproduction of growth hormone. Surgery is identified as primary treatment, but has its limitation, thus frequently requiring alternate treatment options as adjunct to surgery. Stereotactic radiosurgery (SRS) has been used as adjuvant and alternate therapy in patients with inoperable or residual disease; or those not fit for surgery. It has shown reasonable results for treating macroadenoma and tumours invading cavernous sinuses with significant reduction in tumour size and durable endocrinological remission. Factors favouring better outcomes include time from last resection to SRS, older age, peri-procedural withdrawal of medication, higher margin and maximum dose.Hypopituitarism is the most common side effects and requires yearly screening. With the new advances in the field Fractionated-stereotactic radiosurgery and cyber-knife robotic radiosurgery have been introduced with promising preliminary results..

Original languageEnglish
Pages (from-to)1844-1846
Number of pages3
JournalJournal of the Pakistan Medical Association
Issue number12
Publication statusPublished - Dec 2018


  • Acromegaly
  • Pituitary adenoma
  • Radiation therapy


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