TY - JOUR
T1 - Rotavirus infection and disease in a multisite birth cohort
T2 - Results from the MAL-ED study
AU - Mohan, Venkata Raghava
AU - Karthikeyan, Ramanujam
AU - Babji, Sudhir
AU - McGrath, Monica
AU - Shrestha, Sanjaya
AU - Shrestha, Jasmin
AU - Mdumah, Estomih
AU - Amour, Caroline
AU - Samie, Amidou
AU - Nyathi, Emanuel
AU - Haque, Rashidul
AU - Qureshi, Shahida
AU - Yori, Pablo Peñataro
AU - Lima, Aldo A.M.
AU - Bodhidatta, Ladaporn
AU - Svensen, Erling
AU - Bessong, Pascal
AU - Ahmed, Tahmeed
AU - Seidman, Jessica C.
AU - Zaidi, Anita K.M.
AU - Kosek, Margaret N.
AU - Guerrant, Richard L.
AU - Gratz, Jean
AU - Platts-Mills, James A.
AU - Lang, Dennis R.
AU - Gottlieb, Michael
AU - Houpt, Eric R.
AU - Kang, Gagandeep
N1 - Publisher Copyright:
© The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Background: In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs. Methods: Children were recruited by 17 days of age and followed to 24 months with collection of monthly surveillance and diarrheal stools. Data on sociodemographics, feeding, and illness were collected at defined intervals. Stools were tested for rotavirus and sera for antirotavirus immunoglobulins by enzyme immunoassays. Results: A total of 1737 children contributed 22 646 surveillance and 7440 diarrheal specimens. Overall, rotavirus was detected in 5.5% (408/7440) of diarrheal stools, and 344 (19.8%) children ever had rotavirus gastroenteritis. Household overcrowding and a high pathogen load were consistent risk factors for infection and disease. Three prior infections conferred 74% (P < .001) protection against subsequent infection in sites not using vaccine. In Peru, incidence of rotavirus disease was relatively higher during the second year of life despite high vaccination coverage. Conclusions: Rotavirus infection and disease were common, but with significant heterogeneity by site. Protection by vaccination may not be sustained in the second year of life in settings with high burdens of transmission and poor response to oral vaccines.
AB - Background: In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs. Methods: Children were recruited by 17 days of age and followed to 24 months with collection of monthly surveillance and diarrheal stools. Data on sociodemographics, feeding, and illness were collected at defined intervals. Stools were tested for rotavirus and sera for antirotavirus immunoglobulins by enzyme immunoassays. Results: A total of 1737 children contributed 22 646 surveillance and 7440 diarrheal specimens. Overall, rotavirus was detected in 5.5% (408/7440) of diarrheal stools, and 344 (19.8%) children ever had rotavirus gastroenteritis. Household overcrowding and a high pathogen load were consistent risk factors for infection and disease. Three prior infections conferred 74% (P < .001) protection against subsequent infection in sites not using vaccine. In Peru, incidence of rotavirus disease was relatively higher during the second year of life despite high vaccination coverage. Conclusions: Rotavirus infection and disease were common, but with significant heterogeneity by site. Protection by vaccination may not be sustained in the second year of life in settings with high burdens of transmission and poor response to oral vaccines.
KW - Children
KW - Eficacy
KW - Gastroenteritis
KW - Rotavirus
KW - Vaccine
UR - http://www.scopus.com/inward/record.url?scp=85029558751&partnerID=8YFLogxK
U2 - 10.1093/infdis/jix199
DO - 10.1093/infdis/jix199
M3 - Article
C2 - 28472348
AN - SCOPUS:85029558751
SN - 0022-1899
VL - 216
SP - 305
EP - 316
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -
