Rotavirus infection and disease in a multisite birth cohort: Results from the MAL-ED study

Venkata Raghava Mohan, Ramanujam Karthikeyan, Sudhir Babji, Monica McGrath, Sanjaya Shrestha, Jasmin Shrestha, Estomih Mdumah, Caroline Amour, Amidou Samie, Emanuel Nyathi, Rashidul Haque, Shahida Qureshi, Pablo Peñataro Yori, Aldo A.M. Lima, Ladaporn Bodhidatta, Erling Svensen, Pascal Bessong, Tahmeed Ahmed, Jessica C. Seidman, Anita K.M. ZaidiMargaret N. Kosek, Richard L. Guerrant, Jean Gratz, James A. Platts-Mills, Dennis R. Lang, Michael Gottlieb, Eric R. Houpt, Gagandeep Kang

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Background: In a multicountry birth cohort study, we describe rotavirus infection in the first 2 years of life in sites with and without rotavirus vaccination programs. Methods: Children were recruited by 17 days of age and followed to 24 months with collection of monthly surveillance and diarrheal stools. Data on sociodemographics, feeding, and illness were collected at defined intervals. Stools were tested for rotavirus and sera for antirotavirus immunoglobulins by enzyme immunoassays. Results: A total of 1737 children contributed 22 646 surveillance and 7440 diarrheal specimens. Overall, rotavirus was detected in 5.5% (408/7440) of diarrheal stools, and 344 (19.8%) children ever had rotavirus gastroenteritis. Household overcrowding and a high pathogen load were consistent risk factors for infection and disease. Three prior infections conferred 74% (P < .001) protection against subsequent infection in sites not using vaccine. In Peru, incidence of rotavirus disease was relatively higher during the second year of life despite high vaccination coverage. Conclusions: Rotavirus infection and disease were common, but with significant heterogeneity by site. Protection by vaccination may not be sustained in the second year of life in settings with high burdens of transmission and poor response to oral vaccines.

Original languageEnglish
Pages (from-to)305-316
Number of pages12
JournalJournal of Infectious Diseases
Volume216
Issue number3
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • Children
  • Eficacy
  • Gastroenteritis
  • Rotavirus
  • Vaccine

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