S-bridged complex of 99mTc with fac(S)-[Rh(aet)3]: Quality control, characterization and biodistribution studies in rats

N. Amir; S. Roohi; S. Pervez; A. Mushtaq; M. Jehangir; Y. Miyashita; K. Okamoto

doi:10.1007/s10967-007-7244-6

S-bridged complex of ^99mTc with fac(S)-[Rh(aet)₃]: Quality control, characterization and biodistribution studies in rats

N. Amir
, S. Roohi
, S. Pervez
, A. Mushtaq
, M. Jehangir
, Y. Miyashita
, K. Okamoto

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

fac(S)-[Rh(aet)₃] (aet = 2-aminoethanethiolate) is N ₃S₃ metalloligand which can coordinate to transition metal ions to form S-bridge polynuclear complexes. The reaction was carried out between ^99mTcO₄Na and fac(S)-[Rh(aet)₃] in the presence of SnCl₂·2H₂O. A complex analogous to [Re{Rh(aet₃)}₂]³⁺ is formed. A simple method for radiolabeling of fac(S)-[Rh(aet)₃] with ^99mTc has been developed and radiolabeling efficiency was higher than 99%. Effect of SnCl ₂·2H₂O concentration, electrophoresis, HPLC, UV-Visible absorption spectra and biodistribution studies in rats were performed. Higher uptake by kidneys showed rapid distributions of the labeled fac(S)-[Rh(aet)₃]. Liver uptake was significant, stomach, lungs and intestine uptake was high at 4 hours post injection time.

Original language	English (UK)
Pages (from-to)	25-30
Number of pages	6
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	279
Issue number	1
DOIs	https://doi.org/10.1007/s10967-007-7244-6
Publication status	Published - Jan 2009
Externally published	Yes

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10.1007/s10967-007-7244-6

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@article{4a0fd8fb882f4296a6831e530c4d71c0,

title = "S-bridged complex of 99mTc with fac(S)-[Rh(aet)3]: Quality control, characterization and biodistribution studies in rats",

abstract = "fac(S)-[Rh(aet)3] (aet = 2-aminoethanethiolate) is N 3S3 metalloligand which can coordinate to transition metal ions to form S-bridge polynuclear complexes. The reaction was carried out between 99mTcO4Na and fac(S)-[Rh(aet)3] in the presence of SnCl2·2H2O. A complex analogous to [Re\{Rh(aet3)\}2]3+ is formed. A simple method for radiolabeling of fac(S)-[Rh(aet)3] with 99mTc has been developed and radiolabeling efficiency was higher than 99\%. Effect of SnCl 2·2H2O concentration, electrophoresis, HPLC, UV-Visible absorption spectra and biodistribution studies in rats were performed. Higher uptake by kidneys showed rapid distributions of the labeled fac(S)-[Rh(aet)3]. Liver uptake was significant, stomach, lungs and intestine uptake was high at 4 hours post injection time.",

author = "N. Amir and S. Roohi and S. Pervez and A. Mushtaq and M. Jehangir and Y. Miyashita and K. Okamoto",

year = "2009",

month = jan,

doi = "10.1007/s10967-007-7244-6",

language = "English (UK)",

volume = "279",

pages = "25--30",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

issn = "0236-5731",

publisher = "Springer Nature",

number = "1",

}

TY - JOUR

T1 - S-bridged complex of 99mTc with fac(S)-[Rh(aet)3]

T2 - Quality control, characterization and biodistribution studies in rats

AU - Amir, N.

AU - Roohi, S.

AU - Pervez, S.

AU - Mushtaq, A.

AU - Jehangir, M.

AU - Miyashita, Y.

AU - Okamoto, K.

PY - 2009/1

Y1 - 2009/1

N2 - fac(S)-[Rh(aet)3] (aet = 2-aminoethanethiolate) is N 3S3 metalloligand which can coordinate to transition metal ions to form S-bridge polynuclear complexes. The reaction was carried out between 99mTcO4Na and fac(S)-[Rh(aet)3] in the presence of SnCl2·2H2O. A complex analogous to [Re{Rh(aet3)}2]3+ is formed. A simple method for radiolabeling of fac(S)-[Rh(aet)3] with 99mTc has been developed and radiolabeling efficiency was higher than 99%. Effect of SnCl 2·2H2O concentration, electrophoresis, HPLC, UV-Visible absorption spectra and biodistribution studies in rats were performed. Higher uptake by kidneys showed rapid distributions of the labeled fac(S)-[Rh(aet)3]. Liver uptake was significant, stomach, lungs and intestine uptake was high at 4 hours post injection time.

AB - fac(S)-[Rh(aet)3] (aet = 2-aminoethanethiolate) is N 3S3 metalloligand which can coordinate to transition metal ions to form S-bridge polynuclear complexes. The reaction was carried out between 99mTcO4Na and fac(S)-[Rh(aet)3] in the presence of SnCl2·2H2O. A complex analogous to [Re{Rh(aet3)}2]3+ is formed. A simple method for radiolabeling of fac(S)-[Rh(aet)3] with 99mTc has been developed and radiolabeling efficiency was higher than 99%. Effect of SnCl 2·2H2O concentration, electrophoresis, HPLC, UV-Visible absorption spectra and biodistribution studies in rats were performed. Higher uptake by kidneys showed rapid distributions of the labeled fac(S)-[Rh(aet)3]. Liver uptake was significant, stomach, lungs and intestine uptake was high at 4 hours post injection time.

UR - https://www.scopus.com/pages/publications/58149301538

U2 - 10.1007/s10967-007-7244-6

DO - 10.1007/s10967-007-7244-6

M3 - Article

AN - SCOPUS:58149301538

SN - 0236-5731

VL - 279

SP - 25

EP - 30

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 1

ER -

S-bridged complex of ^99mTc with fac(S)-[Rh(aet)₃]: Quality control, characterization and biodistribution studies in rats

Abstract

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