Sample Size Calculation in Medical Research

Musa Karim, Shumaila Furnaz, Ahmed Raheem Buksh, Muhammad Asim Beg, Muhammad Shahbaz Khan, Bushra Moiz

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

For the reliability and general ability of the results of any epidemiological or medical research study, adequate number of study units is extremely important. Study of both less than needed and unnecessarily large sample size is ethically and economically unfair. Considering the importance of sample size, its determination and justification in all kinds of epidemiological or medical research studies, we propose simple and non-technical explanation to the available sample size calculation methods. In this review we covered most frequently encountered study designs in medical research. Present review provides statistical formulas for the sample size calculation of the research studies with varying objectives such as estimation of population proportion(s) and hypothesis testing, estimation of population mean, estimation of diagnostic accuracy, estimation of association and reliability, sample size calculation for case control studies, and sample size calculation for cohort studies. Limited technical details and explanations of underlying theoretical assumption for each method have been included to ensure the adaptability of the method with minimal theoretical understating and statistical knowledge.

Original languageEnglish
Title of host publicationMACS 2019 - 13th International Conference on Mathematics, Actuarial Science, Computer Science and Statistics, Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781728149561
DOIs
Publication statusPublished - Dec 2019
Event13th International Conference on Mathematics, Actuarial Science, Computer Science and Statistics, MACS 2019 - Karachi, Pakistan
Duration: 14 Dec 201915 Dec 2019

Publication series

NameMACS 2019 - 13th International Conference on Mathematics, Actuarial Science, Computer Science and Statistics, Proceedings

Conference

Conference13th International Conference on Mathematics, Actuarial Science, Computer Science and Statistics, MACS 2019
Country/TerritoryPakistan
CityKarachi
Period14/12/1915/12/19

Keywords

  • Association
  • Case Control Studies
  • Cohort Studies
  • Cross-sectional Studies
  • Diagnostic Accuracy
  • Medical Research
  • ROC Curve
  • Reliability
  • Sample Size

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