Screening for tuberculosis in pregnancy: do we need more than a symptom screen? Experience from western Kenya

R J. Kosgei; D Szkwarko; S Callens; P Gichangi; Marleen Temmerman; A-B Kihara; J J. Sitienei; E J. Cheserem; P M. Ndavi; A J. Reid; E J. Carter

Screening for tuberculosis in pregnancy: do we need more than a symptom screen? Experience from western Kenya

R J. Kosgei
, D Szkwarko
, S Callens
, P Gichangi
, Marleen Temmerman
, A-B Kihara
, J J. Sitienei
, E J. Cheserem
, P M. Ndavi
, A J. Reid
, E J. Carter

Centre of Excellence in Women and Child Health, East Africa

Research output: Contribution to journal › Article

17 Downloads (Pure)

Abstract

Objectives: 1) To explore the utility of tuberculosis (TB) symptom screening for symptoms of ⩾2 weeks’ duration in a routine setting, and 2) to compare differences in TB diagnosis between human immunodeficiency virus (HIV) infected and non-HIV-infected pregnant women in western Kenya.

Design: Comparative cross-sectional study among pregnant women with known HIV status screened for TB from 2010 to 2012, in Eldoret, western Kenya.

Results: Of 2983 participants, respectively 34 (1%), 1488 (50.5%) and 1461 (49.5%) had unknown, positive and negative HIV status. The median age was respectively 30 years (interquartile range [IQR] 26–35) and 26 years (IQR 24–31) in HIV-infected and non-infected participants. A positive symptom screen was found in respectively 8% (119/1488) and 5% (67/1461) of the HIV-infected and non-infected women. The median CD4 count at enrolment was 377 cells/μl (IQR 244–530) for HIV-infected women. One non-HIV-infected patient was sputump ositive. For HIV-infected women, TB was presumptively treated in 1% (16/1488) based on clinical symptoms and chest X-ray. Cumulatively, anti-tuberculosis treatment was offered to 0.6% (17/2949) of the participants.

Conclusion: This study does not seem to demonstrate the utility of TB symptom screening questionnaires in a routine setting among pregnant women, either HIV-infected or non-infected, in western Kenya.

Original language	Undefined/Unknown
Journal	Obstetrics and Gynaecology, East Africa
Publication status	Published - 1 Dec 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

Screening for tuberculosis in pregnancy do we need more than a s

http://ecommons.aku.edu/eastafrica_fhs_mc_obstet_gynaecol/334

Cite this

Kosgei, R. J., Szkwarko, D., Callens, S., Gichangi, P., Temmerman, M., Kihara, A.-B., Sitienei, J. J., Cheserem, E. J., Ndavi, P. M., Reid, A. J., & Carter, E. J. (2013). Screening for tuberculosis in pregnancy: do we need more than a symptom screen? Experience from western Kenya. Obstetrics and Gynaecology, East Africa. http://ecommons.aku.edu/eastafrica_fhs_mc_obstet_gynaecol/334

@article{5326cc52a3d04f82b6bf258d35a6c7ac,

title = "Screening for tuberculosis in pregnancy: do we need more than a symptom screen? Experience from western Kenya",

abstract = "Objectives: 1) To explore the utility of tuberculosis (TB) symptom screening for symptoms of ⩾2 weeks{\textquoteright} duration in a routine setting, and 2) to compare differences in TB diagnosis between human immunodeficiency virus (HIV) infected and non-HIV-infected pregnant women in western Kenya. Design: Comparative cross-sectional study among pregnant women with known HIV status screened for TB from 2010 to 2012, in Eldoret, western Kenya. Results: Of 2983 participants, respectively 34 (1\%), 1488 (50.5\%) and 1461 (49.5\%) had unknown, positive and negative HIV status. The median age was respectively 30 years (interquartile range [IQR] 26–35) and 26 years (IQR 24–31) in HIV-infected and non-infected participants. A positive symptom screen was found in respectively 8\% (119/1488) and 5\% (67/1461) of the HIV-infected and non-infected women. The median CD4 count at enrolment was 377 cells/μl (IQR 244–530) for HIV-infected women. One non-HIV-infected patient was sputump ositive. For HIV-infected women, TB was presumptively treated in 1\% (16/1488) based on clinical symptoms and chest X-ray. Cumulatively, anti-tuberculosis treatment was offered to 0.6\% (17/2949) of the participants. Conclusion: This study does not seem to demonstrate the utility of TB symptom screening questionnaires in a routine setting among pregnant women, either HIV-infected or non-infected, in western Kenya.",

author = "Kosgei, \{R J.\} and D Szkwarko and S Callens and P Gichangi and Marleen Temmerman and A-B Kihara and Sitienei, \{J J.\} and Cheserem, \{E J.\} and Ndavi, \{P M.\} and Reid, \{A J.\} and Carter, \{E J.\}",

year = "2013",

month = dec,

day = "1",

language = "Undefined/Unknown",

journal = "Obstetrics and Gynaecology, East Africa",

}

TY - JOUR

T1 - Screening for tuberculosis in pregnancy: do we need more than a symptom screen? Experience from western Kenya

AU - Kosgei, R J.

AU - Szkwarko, D

AU - Callens, S

AU - Gichangi, P

AU - Temmerman, Marleen

AU - Kihara, A-B

AU - Sitienei, J J.

AU - Cheserem, E J.

AU - Ndavi, P M.

AU - Reid, A J.

AU - Carter, E J.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Objectives: 1) To explore the utility of tuberculosis (TB) symptom screening for symptoms of ⩾2 weeks’ duration in a routine setting, and 2) to compare differences in TB diagnosis between human immunodeficiency virus (HIV) infected and non-HIV-infected pregnant women in western Kenya. Design: Comparative cross-sectional study among pregnant women with known HIV status screened for TB from 2010 to 2012, in Eldoret, western Kenya. Results: Of 2983 participants, respectively 34 (1%), 1488 (50.5%) and 1461 (49.5%) had unknown, positive and negative HIV status. The median age was respectively 30 years (interquartile range [IQR] 26–35) and 26 years (IQR 24–31) in HIV-infected and non-infected participants. A positive symptom screen was found in respectively 8% (119/1488) and 5% (67/1461) of the HIV-infected and non-infected women. The median CD4 count at enrolment was 377 cells/μl (IQR 244–530) for HIV-infected women. One non-HIV-infected patient was sputump ositive. For HIV-infected women, TB was presumptively treated in 1% (16/1488) based on clinical symptoms and chest X-ray. Cumulatively, anti-tuberculosis treatment was offered to 0.6% (17/2949) of the participants. Conclusion: This study does not seem to demonstrate the utility of TB symptom screening questionnaires in a routine setting among pregnant women, either HIV-infected or non-infected, in western Kenya.

AB - Objectives: 1) To explore the utility of tuberculosis (TB) symptom screening for symptoms of ⩾2 weeks’ duration in a routine setting, and 2) to compare differences in TB diagnosis between human immunodeficiency virus (HIV) infected and non-HIV-infected pregnant women in western Kenya. Design: Comparative cross-sectional study among pregnant women with known HIV status screened for TB from 2010 to 2012, in Eldoret, western Kenya. Results: Of 2983 participants, respectively 34 (1%), 1488 (50.5%) and 1461 (49.5%) had unknown, positive and negative HIV status. The median age was respectively 30 years (interquartile range [IQR] 26–35) and 26 years (IQR 24–31) in HIV-infected and non-infected participants. A positive symptom screen was found in respectively 8% (119/1488) and 5% (67/1461) of the HIV-infected and non-infected women. The median CD4 count at enrolment was 377 cells/μl (IQR 244–530) for HIV-infected women. One non-HIV-infected patient was sputump ositive. For HIV-infected women, TB was presumptively treated in 1% (16/1488) based on clinical symptoms and chest X-ray. Cumulatively, anti-tuberculosis treatment was offered to 0.6% (17/2949) of the participants. Conclusion: This study does not seem to demonstrate the utility of TB symptom screening questionnaires in a routine setting among pregnant women, either HIV-infected or non-infected, in western Kenya.

M3 - Article

JO - Obstetrics and Gynaecology, East Africa

JF - Obstetrics and Gynaecology, East Africa

ER -