Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

Abdul Momin Kazi; Margaret M. Cortese; Ying Yu; Benjamin Lopman; Ardythe L. Morrow; Jessica A. Fleming; Monica M. McNeal; A. Duncan Steele; Umesh D. Parashar; Anita K.M. Zaidi; Asad Ali

doi:10.1093/infdis/jix028

Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

Abdul Momin Kazi, Margaret M. Cortese, Ying Yu, Benjamin Lopman, Ardythe L. Morrow, Jessica A. Fleming, Monica M. McNeal, A. Duncan Steele, Umesh D. Parashar, Anita K.M. Zaidi, Asad Ali

Department of Obstetrics & Gynaecology, Division of Woman and Child Health, Medical College, Pakistan
Division of Woman and Child Health, Medical College, Pakistan
Department of Paediatrics and Child Health, Division of Woman and Child Health, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

Original language	English
Pages (from-to)	786-789
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	215
Issue number	5
DOIs	https://doi.org/10.1093/infdis/jix028
Publication status	Published - 1 Mar 2017

Keywords

Blood group
FUT2
Infants
Lewis antigen
Rotavirus
Secretor
Vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/infdis/jix028

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title = "Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants",

abstract = "Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.",

keywords = "Blood group, FUT2, Infants, Lewis antigen, Rotavirus, Secretor, Vaccine",

author = "Kazi, {Abdul Momin} and Cortese, {Margaret M.} and Ying Yu and Benjamin Lopman and Morrow, {Ardythe L.} and Fleming, {Jessica A.} and McNeal, {Monica M.} and Steele, {A. Duncan} and Parashar, {Umesh D.} and Zaidi, {Anita K.M.} and Asad Ali",

note = "Funding Information: This work was supported by the Centers for Disease Control and Prevention (contract 200-2015-M-63224) and by PATH (through funding from Gavi).",

year = "2017",

month = mar,

day = "1",

doi = "10.1093/infdis/jix028",

language = "English",

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pages = "786--789",

journal = "Journal of Infectious Diseases",

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T1 - Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

AU - Kazi, Abdul Momin

AU - Cortese, Margaret M.

AU - Yu, Ying

AU - Lopman, Benjamin

AU - Morrow, Ardythe L.

AU - Fleming, Jessica A.

AU - McNeal, Monica M.

AU - Steele, A. Duncan

AU - Parashar, Umesh D.

AU - Zaidi, Anita K.M.

AU - Ali, Asad

N1 - Funding Information: This work was supported by the Centers for Disease Control and Prevention (contract 200-2015-M-63224) and by PATH (through funding from Gavi).

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

AB - Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

KW - Blood group

KW - FUT2

KW - Infants

KW - Lewis antigen

KW - Rotavirus

KW - Secretor

KW - Vaccine

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U2 - 10.1093/infdis/jix028

DO - 10.1093/infdis/jix028

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C2 - 28329092

AN - SCOPUS:85019824340

SN - 0022-1899

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SP - 786

EP - 789

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

IS - 5

ER -

Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

Abstract

Keywords

UN SDGs

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