Secretor and salivary ABO blood group antigen status predict rotavirus vaccine take in infants

Abdul Momin Kazi, Margaret M. Cortese, Ying Yu, Benjamin Lopman, Ardythe L. Morrow, Jessica A. Fleming, Monica M. McNeal, A. Duncan Steele, Umesh D. Parashar, Anita K.M. Zaidi, Asad Ali

Research output: Contribution to journalArticlepeer-review

68 Citations (Scopus)

Abstract

Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.

Original languageEnglish
Pages (from-to)786-789
Number of pages4
JournalJournal of Infectious Diseases
Volume215
Issue number5
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • Blood group
  • FUT2
  • Infants
  • Lewis antigen
  • Rotavirus
  • Secretor
  • Vaccine

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