The most common gynaecological surgical intervention in women is hysterectomy which can be followed by sexual dysfunctions, especially in case of bilateral oophorectomy. Many studies, however, report an improvement of sexual functioning particularly when the hysterectomy was indicated because of excessive bleeding or pain. Cancer of the breast and of the reproductive organs raise the most concern, and special attention is needed for all questions and problems of the patients, including issues of sexual functioning. An underlying depression exerts a profound influence and needs to be recognized and managed. Good communication between the patient, her family and the health care providers, is crucial not only as regards the medical technical aspects but also from a holistic point of view.