Sepsis—In the Era of Antimicrobial Resistance

Rajesh Chandra Mishra, Sharmili Sinha, Reena Shah, Ahsan Ahmed, Ahsina Jahan Lopa

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Sepsis is one of the leading causes of mortality and morbidity across the world. Sepsis caused by multidrug-resistant (MDR) organisms is on the rise globally. Numerous mechanisms responsible for the development of resistance to antibiotics are emerging fast. Rapid diagnostic tests based on polymerase chain reaction technology and others are very useful for quick identification of the causative bacteria and resistant genes in appropriate cases. Early and timely administration of appropriate antibiotics is the cornerstone of antimicrobial therapy for MDR sepsis. Combination therapy should be used for the treatment of MDR sepsis in critically ill patients for best outcomes. Strict implementation of the antibiotic stewardship program is the way forward for preventing emergence and spread of MDR organisms in future.

Original languageEnglish
Title of host publicationThe Sepsis Codex
Number of pages9
ISBN (Electronic)9780323882712
ISBN (Print)9780323882804
Publication statusPublished - 1 Jan 2022


  • Antibiotics
  • Combination therapy
  • Multidrug-resistant organisms
  • Rapid diagnostic test
  • Sepsis


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