Sepsis—In the Era of Antimicrobial Resistance

Sepsis is one of the leading causes of mortality and morbidity across the world. Sepsis caused by multidrug-resistant (MDR) organisms is on the rise globally. Numerous mechanisms responsible for the development of resistance to antibiotics are emerging fast. Rapid diagnostic tests based on polymerase chain reaction technology and others are very useful for quick identification of the causative bacteria and resistant genes in appropriate cases. Early and timely administration of appropriate antibiotics is the cornerstone of antimicrobial therapy for MDR sepsis. Combination therapy should be used for the treatment of MDR sepsis in critically ill patients for best outcomes. Strict implementation of the antibiotic stewardship program is the way forward for preventing emergence and spread of MDR organisms in future.