TY - JOUR
T1 - Serum liquid biopsy for brain tumours
T2 - a scoping analysis of practicable approaches in low- and middle-income countries
AU - Bajwa, Mohammad Hamza
AU - Khan, Muhammad Awais
AU - Urooj, Faiza
AU - Khalid, Muhammad Usman
AU - Enam, Syed Ather
AU - Aziz, Hafiza Fatima
AU - Siddiqui, Kaynat
AU - Bari, Muhammad Ehsan
AU - Mughal, Nouman
PY - 2024/3/1
Y1 - 2024/3/1
N2 - Approaches to brain tumour diagnosis and detecting recurrence after treatment are costly and significantly invasive. Developing peripheral-sample liquid biopsy tools is the key to enhancing our ability to prognosticate brain tumour subtypes and molecular heterogeneity. The present scoping review was designed to discuss current updates in liquid biopsy tools for diagnosis and guiding clinical management of brain tumours; we evaluated the literature within the context of low-and-middle-income country challenges. Circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), cell-free DNA (cfDNA), extracellular vesicle-associated biomarkers, protein biomarkers, microRNAs, and serum metabolites are discussed with the collation of current data supporting their utility in liquid biopsy. Further challenges to implanting liquid biopsy tools at a systematic level are highlighted.
AB - Approaches to brain tumour diagnosis and detecting recurrence after treatment are costly and significantly invasive. Developing peripheral-sample liquid biopsy tools is the key to enhancing our ability to prognosticate brain tumour subtypes and molecular heterogeneity. The present scoping review was designed to discuss current updates in liquid biopsy tools for diagnosis and guiding clinical management of brain tumours; we evaluated the literature within the context of low-and-middle-income country challenges. Circulating tumour cells (CTCs), circulating tumour DNA (ctDNA), cell-free DNA (cfDNA), extracellular vesicle-associated biomarkers, protein biomarkers, microRNAs, and serum metabolites are discussed with the collation of current data supporting their utility in liquid biopsy. Further challenges to implanting liquid biopsy tools at a systematic level are highlighted.
KW - Tumour, DNA, Neoplastic Cells, Liquid Biopsy, Brain Neoplasms, MicroRNAs, Extracellular Vesicles
UR - http://www.scopus.com/inward/record.url?scp=85204089988&partnerID=8YFLogxK
U2 - 10.47391/JPMA.S3.GNO-06
DO - 10.47391/JPMA.S3.GNO-06
M3 - Review article
C2 - 39262064
AN - SCOPUS:85204089988
SN - 0030-9982
VL - 74
SP - S30-S51
JO - JPMA. The Journal of the Pakistan Medical Association
JF - JPMA. The Journal of the Pakistan Medical Association
IS - 3 3
ER -