Severe malarial anemia is associated with long-term neurocognitive impairment.

Paul Bangirana Bangirana; Robert Opoka; Michael J. Boivin; Richard Idro; James S. Hodges; Regilda A. Romero; Elsa Shapiro; Chandy C. John

doi:10.1093/cid/ciu293

Severe malarial anemia is associated with long-term neurocognitive impairment.

Paul Bangirana Bangirana, Robert Opoka, Michael J. Boivin, Richard Idro, James S. Hodges, Regilda A. Romero, Elsa Shapiro, Chandy C. John

Medical College, East Africa

Research output: Contribution to journal › Article

105 Citations (Scopus)

Abstract

Background. Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children ≥5 years of age. No prospective studies to date have assessed neurocognitive impairment in children with CM

Methods. Children z scores for each domain were computed based on scores of 61 healthy community children (CC), who were also tested at enrollment and 6 and 12 months later. Groups were compared using mixed linear models, adjusted for age, weight for age, and child's education.

Results. At 12 months, children with CM had lower adjusted scores than CC in cognitive ability (P < .001), attention (P = .02), and associative memory, (P = .002). Children with SMA had lower scores than CC in cognitive ability (P = .01) but not attention or associative memory. Cognitive ability scores in children with CM and SMA did not differ significantly.

Conclusions. In children

Original language	Undefined/Unknown
Journal	Paediatrics and Child Health, East Africa
DOIs	https://doi.org/10.1093/cid/ciu293
Publication status	Published - 1 Aug 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/ciu293Licence: Unspecified

http://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/391

Cite this

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title = "Severe malarial anemia is associated with long-term neurocognitive impairment.",

abstract = "Background. Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children ≥5 years of age. No prospective studies to date have assessed neurocognitive impairment in children with CM Methods. Children z scores for each domain were computed based on scores of 61 healthy community children (CC), who were also tested at enrollment and 6 and 12 months later. Groups were compared using mixed linear models, adjusted for age, weight for age, and child's education. Results. At 12 months, children with CM had lower adjusted scores than CC in cognitive ability (P < .001), attention (P = .02), and associative memory, (P = .002). Children with SMA had lower scores than CC in cognitive ability (P = .01) but not attention or associative memory. Cognitive ability scores in children with CM and SMA did not differ significantly. Conclusions. In children ",

author = "Bangirana, {Paul Bangirana} and Robert Opoka and Boivin, {Michael J.} and Richard Idro and Hodges, {James S.} and Romero, {Regilda A.} and Elsa Shapiro and John, {Chandy C.}",

year = "2012",

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doi = "10.1093/cid/ciu293",

language = "Undefined/Unknown",

journal = "Paediatrics and Child Health, East Africa",

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TY - JOUR

T1 - Severe malarial anemia is associated with long-term neurocognitive impairment.

AU - Bangirana, Paul Bangirana

AU - Opoka, Robert

AU - Boivin, Michael J.

AU - Idro, Richard

AU - Hodges, James S.

AU - Romero, Regilda A.

AU - Shapiro, Elsa

AU - John, Chandy C.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Background. Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children ≥5 years of age. No prospective studies to date have assessed neurocognitive impairment in children with CM Methods. Children z scores for each domain were computed based on scores of 61 healthy community children (CC), who were also tested at enrollment and 6 and 12 months later. Groups were compared using mixed linear models, adjusted for age, weight for age, and child's education. Results. At 12 months, children with CM had lower adjusted scores than CC in cognitive ability (P < .001), attention (P = .02), and associative memory, (P = .002). Children with SMA had lower scores than CC in cognitive ability (P = .01) but not attention or associative memory. Cognitive ability scores in children with CM and SMA did not differ significantly. Conclusions. In children

AB - Background. Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children ≥5 years of age. No prospective studies to date have assessed neurocognitive impairment in children with CM Methods. Children z scores for each domain were computed based on scores of 61 healthy community children (CC), who were also tested at enrollment and 6 and 12 months later. Groups were compared using mixed linear models, adjusted for age, weight for age, and child's education. Results. At 12 months, children with CM had lower adjusted scores than CC in cognitive ability (P < .001), attention (P = .02), and associative memory, (P = .002). Children with SMA had lower scores than CC in cognitive ability (P = .01) but not attention or associative memory. Cognitive ability scores in children with CM and SMA did not differ significantly. Conclusions. In children

U2 - 10.1093/cid/ciu293

DO - 10.1093/cid/ciu293

M3 - Article

JO - Paediatrics and Child Health, East Africa

JF - Paediatrics and Child Health, East Africa

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