Severe malarial anemia is associated with long-term neurocognitive impairment.

Paul Bangirana Bangirana, Robert Opoka, Michael J. Boivin, Richard Idro, James S. Hodges, Regilda A. Romero, Elsa Shapiro, Chandy C. John

Research output: Contribution to journalArticle


Background. Cerebral malaria (CM) is associated with long-term neurocognitive impairment in children ≥5 years of age. No prospective studies to date have assessed neurocognitive impairment in children with CM

Methods. Children z scores for each domain were computed based on scores of 61 healthy community children (CC), who were also tested at enrollment and 6 and 12 months later. Groups were compared using mixed linear models, adjusted for age, weight for age, and child's education.

Results. At 12 months, children with CM had lower adjusted scores than CC in cognitive ability (P < .001), attention (P = .02), and associative memory, (P = .002). Children with SMA had lower scores than CC in cognitive ability (P = .01) but not attention or associative memory. Cognitive ability scores in children with CM and SMA did not differ significantly.

Conclusions. In children

Original languageUndefined/Unknown
JournalPaediatrics and Child Health, East Africa
Publication statusPublished - 1 Aug 2012

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