Severe propylthiouracil-induced hepatotoxicity in pregnancy managed successfully by liver transplantation: A case report

Evan Sequeira, Sikolia Wanyonyi, Raj Dodia

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22 Citations (Scopus)

Abstract

Introduction. Propylthiouracil-induced severe hepatotoxicity is a relatively rare occurrence, with very few cases reported in the literature. The management of this complication in pregnancy can be a challenge because of the effects of the various treatment options on the fetus. Case presentation. We report a rare case of fulminant hepatic failure in a 36-year-old gravida 2 black woman of African descent that occurred at 17 weeks gestation following propylthiouracil treatment for Graves' disease. Her liver failure was managed by liver transplantation and thyroidectomy. Her pregnancy was continued to term, though with not so favorable early childhood sequelae. Conclusion: This case illustrates a very rare complication of treatment with a presumed safe drug during pregnancy followed by adverse neonatal outcomes due to the extensive treatment.

Original languageEnglish
Article number461
JournalJournal of Medical Case Reports
Volume5
DOIs
Publication statusPublished - 2011

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