Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19

Adrian Scutelnic, Anita van de Munckhof, Katarzyna Krzywicka, Mayte Sánchez van Kammen, Erik Lindgren, Charlotte Cordonnier, Timothy J. Kleinig, Thalia S. Field, Sven Poli, Robin Lemmens, Saskia Middeldorp, Sanjith Aaron, Afshin Borhani-Haghighi, Antonio Arauz, Johanna A. Kremer Hovinga, Albrecht Günther, Jukka Putaala, Mohammad Wasay, Adriana Bastos Conforto, Diana Aguiar de SousaKatarina Jood, Turgut Tatlisumak, José M. Ferro, Jonathan M. Coutinho, Marcel Arnold, Mirjam R. Heldner, Kateryna Antonenko, Joshua Mbroh, Justine Brodard, Etrat Hooshmandi, Vanessa Dizonno, Annemie Devroye, Alfonso Ciccone, Matthias Wittstock, Julian Zimmermann, Felix J. Bode, Mona Skjelland, Jiangang Duan, Sini Hiltunen, Susanna M. Zuurbier, Marco Petruzzellis, Aarti R. Sharma, Abdoreza Ghoreishi, Ahmed Elkady, Alberto Negro, Alexander Gutschalk, Silvia Schoenenberger, Simon Nagel, Alina Buture, Alvaro Cervera, Ana Paiva Nunes, Ana Romina Montané Baños, Andreas Tiede, Anemon Puthuppallil, Anil M. Tuladhar, Annerose Mengel, Antonio Medina, Åslög Hellström Vogel, Audrey Tawa, Avinash Aujayeb, Balakrishnan Ramasamy, Barbara Casolla, Beng Lim Alvin Chew, Bentalhoda Ziaadini, Boby Varkey Maramattom, Brian Buck, Carla Zanferrari, Carlos Garcia-Esperon, Caroline Vayne, Catherine Legault, Christian Jacobi, Christian Pfrepper, Johann Pelz, Christoph Wahl, Rolf Kern, Clement Tracol, Cristina Soriano, Daniel Guisado-Alonso, David Bougon, Deepti Bal, Domenico Sergio Zimatore, Dominik Michalski, Dylan Blacquiere, Elias Johansson, Elisa Cuadrado-Godia, Elyar Sadeghi-Hokmabadi, Emmanuel Carrera, Emmanuel De Maistre, Espen Saxhaug Kristoffersen, Fabrice Bonneville, Thomas Geeraerts, Fabrice Vuillier, Fabrizio Giammello, Florindo D’Onofrio, Francesco Grillo, François Caparros, Sophie Susen, Frank Maier, Georgios Tsivgoulis, Giosue Gulli, Giovanni Frisullo, Guillaume Franchineau, Hakan Cangür, Hans Katzberg, Hossein Mozhdehipanah, Igor Sibon, M. Irem Baharoglu, Jaime Masjuan, Jaskiran Brar, Jean Francois Payen, Jim Burrow, João Fernandes, Jorge Octavio López Esparza, Joyce Oen, Judith Schouten, Karl Ng, Sophie Chatterton, Miriam Wronski, Katharina Althaus, Katia Garambois, Laurent Derex, Laurent Puy, Leila Poorsaadat, Lenise Valler, Letícia Januzi de Almeida Rocha, Lisa Humbertjean, Lucia Lebrato Hernandez, Luis Murillo-Bonilla, Lukas Kellermair, Mar Morin Martin, Maria Sofia Cotelli, Maria Hernandez Perez, Marialuisa Zedde, Mariana Carvalho Dias, Marie Cecile Dubois, Marta Carvalho, Masoud Ghiasian, Meenakshisundaram Umaiorubahan, Ravi Kumar Karunakaran, Mehrdad Roozbeh, Michele Romoli, Miguel Miranda, Mohammad Saadatnia, Monica Bandettini di Poggio, Moritz J. Scholz, Robert Kahnis, Mostafa Almasi-Dooghaee, Nahid Hoseininejad Mir, Nasli R. Ichaporia, Naveen Kumar Paramasivan, Sapna Erat Sreedharan, P. N. Sylaja, Nicolas Raposo, Nima Fadakar, Nyika Kruyt, Olivier Detante, Pauline Cuisenier, Olivier Huet, Pankaj Sharma, Paolo Candelaresi, Pasquale Scoppettuolo, Peggy Reiner, Reza Nemati, Ricardo Vieira, Rudy Goh, Seán Murphy, Serge Timsit, Shelagh Coutts, Shyam S. Sharma, Simerpreet Bal, Subhash Kaul, Theodoros Karapanayiotides, Thomas Cox, Thomas Gattringer, Thomas Mathew, Thorsten Bartsch, Vahid Shaygannejad, Veronica Garcia-Talavera, Vincenzo Palma, Yıldız Arslan, Zahra Mirzaasgari, Zeinab Yavari, Zohreh Zamani, Tamam Bakchoul, Marcel Levi, Eric C.M. van Gorp

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Introduction: Cerebral venous sinus thrombosis associated with vaccine-induced immune thrombotic thrombocytopenia (CVST-VITT) is a severe disease with high mortality. There are few data on sex differences in CVST-VITT. The aim of our study was to investigate the differences in presentation, treatment, clinical course, complications, and outcome of CVST-VITT between women and men. Patients and methods: We used data from an ongoing international registry on CVST-VITT. VITT was diagnosed according to the Pavord criteria. We compared the characteristics of CVST-VITT in women and men. Results: Of 133 patients with possible, probable, or definite CVST-VITT, 102 (77%) were women. Women were slightly younger [median age 42 (IQR 28–54) vs 45 (28–56)], presented more often with coma (26% vs 10%) and had a lower platelet count at presentation [median (IQR) 50x109/L (28–79) vs 68 (30–125)] than men. The nadir platelet count was lower in women [median (IQR) 34 (19–62) vs 53 (20–92)]. More women received endovascular treatment than men (15% vs 6%). Rates of treatment with intravenous immunoglobulins were similar (63% vs 66%), as were new venous thromboembolic events (14% vs 14%) and major bleeding complications (30% vs 20%). Rates of good functional outcome (modified Rankin Scale 0-2, 42% vs 45%) and in-hospital death (39% vs 41%) did not differ. Discussion and conclusions: Three quarters of CVST-VITT patients in this study were women. Women were more severely affected at presentation, but clinical course and outcome did not differ between women and men. VITT-specific treatments were overall similar, but more women received endovascular treatment.

Original languageEnglish
Pages (from-to)1001-1010
Number of pages10
JournalEuropean Stroke Journal
Volume8
Issue number4
DOIs
Publication statusPublished - Dec 2023

Keywords

  • CVST
  • VITT
  • sex differences

Fingerprint

Dive into the research topics of 'Sex differences in cerebral venous sinus thrombosis after adenoviral vaccination against COVID-19'. Together they form a unique fingerprint.

Cite this