Short term outcome and predictors of response to neoadjuvant treatment in rectal cancer

Rizwan Sultan, Tabish Chawla, Mirza Aman Beg

Research output: Contribution to journalArticlepeer-review


Objective: To evaluate response to neoadjuvant chemoradiation in the treatment of rectal cancer and to see if it can be predicted whether a particular patient will benefit from such treatment. Methods: The retrospective case series was done at the Aga Khan University Hospital, Karachi, and comprised data related to period from January 2005 to December 2014 of patients with rectal cancer who had received neoadjuvant treatment. They were divided into responders and non-responders on the basis of imaging. Pre-treatment factors were compared to identify differences in the two groups. SPSS 19 was used for statistical analysis. Results: The median age of 35 patients whose records were studied was 44 years (interquartile range: 33-54). Response to neoadjuvant treatment was seen in 13(37%) patients with complete pathological response in 8(22.9%). There was no statistically significant difference in age, gender, pre-treatment tumour stage, tumour biology and distance from anal verge among the responders and the non-responders (p>0.05 each). Conclusion: Response to neoadjuvant treatment in rectal cancer was low.

Original languageEnglish
Pages (from-to)1065-1068
Number of pages4
JournalJournal of the Pakistan Medical Association
Issue number10
Publication statusPublished - Oct 2015


  • Karachi
  • Neoadjuvant chemoradiation
  • Rectal cancer


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