Significance of micro-RNA expression in patients with meningioma

Rida Mitha, Muhammad Shahzad Shamim

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Recent brain tumour research has shown abnormalities in gene expression as key features for almost all common brain tumours investigated. However, there is increasing evidence that epigenetic abnormalities are also crucial for tumorigenesis. Epigenetic abnormalities are heritable alterations affecting gene expression without changing the primary DNA sequence. Epigenetic abnormalities in meningiomas include abnormal microRNA expression, altered DNA methylation and histone and chromatin modifications. In this review we identify the role of altered expression of microRNA in the development and recurrence of meningioma. Based on the review of current literature, extensive knowledge of micro-RNA expression cannot only determine tumour recurrence and prognosis but also opens up new avenues for treatment.

Original languageEnglish
Pages (from-to)1287-1288
Number of pages2
JournalJPMA. The Journal of the Pakistan Medical Association
Issue number7
Publication statusPublished - 1 Jul 2020


  • Brain tumor, Meningioma, miro-RNA, Epigenetics.


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