Size or the number of portal tracts: Which matters in a liver biopsy core in chronic hepatitis C?

Om Parkash; Khalid Mumtaz; Zubair Ahmed; Saeed Hamid; Fatima Jafri; Wasim Jafri

Size or the number of portal tracts: Which matters in a liver biopsy core in chronic hepatitis C?

Om Parkash, Khalid Mumtaz, Zubair Ahmed, Saeed Hamid, Fatima Jafri, Wasim Jafri

Department of Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Liver biopsy has an important role in staging of fibrosis (SoF) and grading of inflammation (GoI) in chronic hepatitis C (CHC) patients. The effect of size and number of portal tracts (NoP) on grading and staging of liver biopsy was evaluated. A total of 150 consecutive liver biopsy core (LBC) of patients with CHC were obtained. There were 98 (65.3%) males. Mean length of LBC was 1.45 ± 0.48 cm. Mean number of portal tracts (NoP) was 11±4.6. Mean length of LBC was greater (1.60±0.45 cm) in stage 4 (n=41; 27.3%) and lesser (1.28+0.39) in stage 1 (n=23; 15%, p=0.04). The mean NoP were 8.5, 10.6 and 13.1 in GoI 1, 2 and 3 respectively (p < 0.001). The mean NoP were 7.6, 11.1, 11.3 and 14.5 in SoF 1, 2, 3 and 4 respectively (p < 0.0001). There was a good correlation between number of portal tracts and length of LBC (r²=0.56).

Original language	English
Pages (from-to)	121-122
Number of pages	2
Journal	Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
Volume	21
Issue number	2
Publication status	Published - Feb 2011

Keywords

Fibrosis
Grade
Hepatitis C
Inflammation
Liver biopsy
Portal tract
Stage

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Size or the number of portal tracts: Which matters in a liver biopsy core in chronic hepatitis C?",

abstract = "Liver biopsy has an important role in staging of fibrosis (SoF) and grading of inflammation (GoI) in chronic hepatitis C (CHC) patients. The effect of size and number of portal tracts (NoP) on grading and staging of liver biopsy was evaluated. A total of 150 consecutive liver biopsy core (LBC) of patients with CHC were obtained. There were 98 (65.3%) males. Mean length of LBC was 1.45 ± 0.48 cm. Mean number of portal tracts (NoP) was 11±4.6. Mean length of LBC was greater (1.60±0.45 cm) in stage 4 (n=41; 27.3%) and lesser (1.28+0.39) in stage 1 (n=23; 15%, p=0.04). The mean NoP were 8.5, 10.6 and 13.1 in GoI 1, 2 and 3 respectively (p < 0.001). The mean NoP were 7.6, 11.1, 11.3 and 14.5 in SoF 1, 2, 3 and 4 respectively (p < 0.0001). There was a good correlation between number of portal tracts and length of LBC (r2=0.56).",

keywords = "Fibrosis, Grade, Hepatitis C, Inflammation, Liver biopsy, Portal tract, Stage",

author = "Om Parkash and Khalid Mumtaz and Zubair Ahmed and Saeed Hamid and Fatima Jafri and Wasim Jafri",

year = "2011",

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pages = "121--122",

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TY - JOUR

T1 - Size or the number of portal tracts

T2 - Which matters in a liver biopsy core in chronic hepatitis C?

AU - Parkash, Om

AU - Mumtaz, Khalid

AU - Ahmed, Zubair

AU - Hamid, Saeed

AU - Jafri, Fatima

AU - Jafri, Wasim

PY - 2011/2

Y1 - 2011/2

N2 - Liver biopsy has an important role in staging of fibrosis (SoF) and grading of inflammation (GoI) in chronic hepatitis C (CHC) patients. The effect of size and number of portal tracts (NoP) on grading and staging of liver biopsy was evaluated. A total of 150 consecutive liver biopsy core (LBC) of patients with CHC were obtained. There were 98 (65.3%) males. Mean length of LBC was 1.45 ± 0.48 cm. Mean number of portal tracts (NoP) was 11±4.6. Mean length of LBC was greater (1.60±0.45 cm) in stage 4 (n=41; 27.3%) and lesser (1.28+0.39) in stage 1 (n=23; 15%, p=0.04). The mean NoP were 8.5, 10.6 and 13.1 in GoI 1, 2 and 3 respectively (p < 0.001). The mean NoP were 7.6, 11.1, 11.3 and 14.5 in SoF 1, 2, 3 and 4 respectively (p < 0.0001). There was a good correlation between number of portal tracts and length of LBC (r2=0.56).

AB - Liver biopsy has an important role in staging of fibrosis (SoF) and grading of inflammation (GoI) in chronic hepatitis C (CHC) patients. The effect of size and number of portal tracts (NoP) on grading and staging of liver biopsy was evaluated. A total of 150 consecutive liver biopsy core (LBC) of patients with CHC were obtained. There were 98 (65.3%) males. Mean length of LBC was 1.45 ± 0.48 cm. Mean number of portal tracts (NoP) was 11±4.6. Mean length of LBC was greater (1.60±0.45 cm) in stage 4 (n=41; 27.3%) and lesser (1.28+0.39) in stage 1 (n=23; 15%, p=0.04). The mean NoP were 8.5, 10.6 and 13.1 in GoI 1, 2 and 3 respectively (p < 0.001). The mean NoP were 7.6, 11.1, 11.3 and 14.5 in SoF 1, 2, 3 and 4 respectively (p < 0.0001). There was a good correlation between number of portal tracts and length of LBC (r2=0.56).

KW - Fibrosis

KW - Grade

KW - Hepatitis C

KW - Inflammation

KW - Liver biopsy

KW - Portal tract

KW - Stage

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JO - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

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ER -

Size or the number of portal tracts: Which matters in a liver biopsy core in chronic hepatitis C?

Abstract

Keywords

UN SDGs

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