Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.

Michael Hawkes; Andrea L. Conroy; Robert Opoka; Sophie Namasopo; Kathleen Zhong; W. Conrad Liles; Chandy C. John; Kevin C. Kain

doi:10.3201/eid2107.150213

Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.

Michael Hawkes
, Andrea L. Conroy
, Robert Opoka
, Sophie Namasopo
, Kathleen Zhong
, W. Conrad Liles
, Chandy C. John
, Kevin C. Kain

Medical College, East Africa

Research output: Contribution to journal › Article

46 Citations (Scopus)

Abstract

Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.

Original language	Undefined/Unknown
Journal	Paediatrics and Child Health, East Africa
DOIs	https://doi.org/10.3201/eid2107.150213
Publication status	Published - 1 Jul 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.3201/eid2107.150213Licence: Unspecified

http://ecommons.aku.edu/eastafrica_fhs_mc_paediatr_child_health/382

Cite this

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title = "Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.",

abstract = "Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.",

author = "Michael Hawkes and Conroy, \{Andrea L.\} and Robert Opoka and Sophie Namasopo and Kathleen Zhong and Liles, \{W. Conrad\} and John, \{Chandy C.\} and Kain, \{Kevin C.\}",

year = "2015",

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doi = "10.3201/eid2107.150213",

language = "Undefined/Unknown",

journal = "Paediatrics and Child Health, East Africa",

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T1 - Slow Clearance of Plasmodium falciparum in Severe Pediatric Malaria, Uganda, 2011-2013.

AU - Hawkes, Michael

AU - Conroy, Andrea L.

AU - Opoka, Robert

AU - Namasopo, Sophie

AU - Zhong, Kathleen

AU - Liles, W. Conrad

AU - John, Chandy C.

AU - Kain, Kevin C.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.

AB - Plasmodium falciparum resistance to artemisinin derivatives is emerging in Asia. We examined molecular markers of resistance in 78 children in Uganda who had severe malaria and were treated with intravenous artesunate. We observed in the K13-propeller domain, A578S, a low-frequency (3/78), nonsynonymous, single-nucleotide polymorphism associated with prolonged parasite clearance.

U2 - 10.3201/eid2107.150213

DO - 10.3201/eid2107.150213

M3 - Article

JO - Paediatrics and Child Health, East Africa

JF - Paediatrics and Child Health, East Africa

ER -