Sodium fluorescein guided resection of malignant glioma

Muhammad Waqas, Muhammad Shahzad Shamim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The average rate of gross total resection (GTR) for malignant gliomas (MGs) is reported to be around 36%. One of the major challenges to GTR is the recognition of tumour margins. Sodium fluorescein is a freely available fluorophore used to recognize the boundaries of MGs. It accumulates in tumour areas with disrupted blood brain barrier that can then be visualized under a microscope with dedicated filters. No randomized controlled trial or meta-analysis is available that reports the impact of fluorescein use on the extent of tumour resection. Several prospective studies and a phase II trial prove it to be safe and helpful in achieving GTR rates of 68.42-100%. At higher doses i.e., 15-20 mg/Kg, sodium fluorescein can even be used under white illumination. The dye is safe even at high doses and has helped achieve GTR rates of 80-84.4%.

Original languageEnglish
Pages (from-to)968-970
Number of pages3
JournalJournal of the Pakistan Medical Association
Volume68
Issue number6
Publication statusPublished - Jun 2018

Keywords

  • Gross total resection
  • Malignant gliomas
  • Sodium fluorescein

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