Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings

Usman Ahmed; Jeremy Soo; Andrea L. Conroy; Sophie Namasopo; Robert O. Opoka; Ravi Bhargava; Michael T. Hawkes

doi:10.1016/j.cyto.2022.155794

Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings

Usman Ahmed, Jeremy Soo, Andrea L. Conroy, Sophie Namasopo, Robert O. Opoka, Ravi Bhargava, Michael T. Hawkes

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

In a prospective cohort study of 77 children with severe pneumonia from two hospitals in Uganda, we assessed soluble T cell immunoglobulin and mucin-domain containing protein 3 (sTIM-3) levels at hospital admission and their association with pneumonia severity and subsequent mortality. sTIM-3 levels were positively correlated with the Respiratory Index of Severity in Children (RISC) (ρ = 0.35, p = 0.0017), sTIM-3 levels were higher in children who required transfer to a tertiary hospital (p = 0.014) and in fatal cases (p = 0.011). In summary, sTIM-3 is associated with disease severity and predictive of mortality in childhood pneumonia in resource-limited settings.

Original language	English
Article number	155794
Journal	Cytokine
Volume	151
DOIs	https://doi.org/10.1016/j.cyto.2022.155794
Publication status	Published - Mar 2022
Externally published	Yes

Keywords

Africa
Biomarker
Pediatric pneumonia
Prospective cohort study
Respiratory Index of Severity in Children
sTIM-3

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10.1016/j.cyto.2022.155794

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title = "Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings",

abstract = "In a prospective cohort study of 77 children with severe pneumonia from two hospitals in Uganda, we assessed soluble T cell immunoglobulin and mucin-domain containing protein 3 (sTIM-3) levels at hospital admission and their association with pneumonia severity and subsequent mortality. sTIM-3 levels were positively correlated with the Respiratory Index of Severity in Children (RISC) (ρ = 0.35, p = 0.0017), sTIM-3 levels were higher in children who required transfer to a tertiary hospital (p = 0.014) and in fatal cases (p = 0.011). In summary, sTIM-3 is associated with disease severity and predictive of mortality in childhood pneumonia in resource-limited settings.",

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author = "Usman Ahmed and Jeremy Soo and Conroy, {Andrea L.} and Sophie Namasopo and Opoka, {Robert O.} and Ravi Bhargava and Hawkes, {Michael T.}",

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doi = "10.1016/j.cyto.2022.155794",

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T1 - Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings

AU - Ahmed, Usman

AU - Soo, Jeremy

AU - Conroy, Andrea L.

AU - Namasopo, Sophie

AU - Opoka, Robert O.

AU - Bhargava, Ravi

AU - Hawkes, Michael T.

PY - 2022/3

Y1 - 2022/3

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AB - In a prospective cohort study of 77 children with severe pneumonia from two hospitals in Uganda, we assessed soluble T cell immunoglobulin and mucin-domain containing protein 3 (sTIM-3) levels at hospital admission and their association with pneumonia severity and subsequent mortality. sTIM-3 levels were positively correlated with the Respiratory Index of Severity in Children (RISC) (ρ = 0.35, p = 0.0017), sTIM-3 levels were higher in children who required transfer to a tertiary hospital (p = 0.014) and in fatal cases (p = 0.011). In summary, sTIM-3 is associated with disease severity and predictive of mortality in childhood pneumonia in resource-limited settings.

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KW - Biomarker

KW - Pediatric pneumonia

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Soluble T cell immunoglobulin and mucin-domain containing protein 3 in children hospitalized with pneumonia in resource-limited settings

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Keywords

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