Soluble Urokinase-Type Plasminogen Activator Receptor as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria

Veselina Stefanova; Michelle Ngai; Andrea M. Weckman; Julie K. Wright; Kathleen Zhong; Melissa Richard-Greenblatt; Chloe R. McDonald; Andrea L. Conroy; Sophie Namasopo; Robert O. Opoka; Michael Hawkes; Kevin C. Kain

doi:10.1093/cid/ciac457

Soluble Urokinase-Type Plasminogen Activator Receptor as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria

Veselina Stefanova
, Michelle Ngai
, Andrea M. Weckman
, Julie K. Wright
, Kathleen Zhong
, Melissa Richard-Greenblatt
, Chloe R. McDonald
, Andrea L. Conroy
, Sophie Namasopo
, Robert O. Opoka
, Michael Hawkes
, Kevin C. Kain

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: Current malaria diagnostic tests do not reliably identify children at risk of severe and fatal infection. Host immune and endothelial activation contribute to malaria pathogenesis. Soluble urokinase-Type plasminogen activator receptor (suPAR) is a marker of these pathways. We hypothesized that measuring suPAR at presentation could risk-stratify children with malaria. Methods: Plasma suPAR levels were determined in consecutive febrile children with malaria at presentation to hospital in Jinja, Uganda.

Original language	English (US)
Pages (from-to)	E1079-E1086
Journal	Clinical Infectious Diseases
Volume	76
Issue number	3
DOIs	https://doi.org/10.1093/cid/ciac457
Publication status	Published - 1 Feb 2023
Externally published	Yes

Keywords

mortality outcome
prognostic marker
risk-stratification
severe malaria
soluble urokinase-Type plasminogen activator receptor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/ciac457

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Stefanova, V., Ngai, M., Weckman, A. M., Wright, J. K., Zhong, K., Richard-Greenblatt, M., McDonald, C. R., Conroy, A. L., Namasopo, S., Opoka, R. O., Hawkes, M., & Kain, K. C. (2023). Soluble Urokinase-Type Plasminogen Activator Receptor as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria. Clinical Infectious Diseases, 76(3), E1079-E1086. https://doi.org/10.1093/cid/ciac457

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title = "Soluble Urokinase-Type Plasminogen Activator Receptor as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria",

abstract = "Background: Current malaria diagnostic tests do not reliably identify children at risk of severe and fatal infection. Host immune and endothelial activation contribute to malaria pathogenesis. Soluble urokinase-Type plasminogen activator receptor (suPAR) is a marker of these pathways. We hypothesized that measuring suPAR at presentation could risk-stratify children with malaria. Methods: Plasma suPAR levels were determined in consecutive febrile children with malaria at presentation to hospital in Jinja, Uganda.",

keywords = "mortality outcome, prognostic marker, risk-stratification, severe malaria, soluble urokinase-Type plasminogen activator receptor",

author = "Veselina Stefanova and Michelle Ngai and Weckman, \{Andrea M.\} and Wright, \{Julie K.\} and Kathleen Zhong and Melissa Richard-Greenblatt and McDonald, \{Chloe R.\} and Conroy, \{Andrea L.\} and Sophie Namasopo and Opoka, \{Robert O.\} and Michael Hawkes and Kain, \{Kevin C.\}",

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year = "2023",

month = feb,

day = "1",

doi = "10.1093/cid/ciac457",

language = "English (US)",

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Stefanova, V, Ngai, M, Weckman, AM, Wright, JK, Zhong, K, Richard-Greenblatt, M, McDonald, CR, Conroy, AL, Namasopo, S, Opoka, RO, Hawkes, M & Kain, KC 2023, 'Soluble Urokinase-Type Plasminogen Activator Receptor as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria', Clinical Infectious Diseases, vol. 76, no. 3, pp. E1079-E1086. https://doi.org/10.1093/cid/ciac457

TY - JOUR

T1 - Soluble Urokinase-Type Plasminogen Activator Receptor as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria

AU - Stefanova, Veselina

AU - Ngai, Michelle

AU - Weckman, Andrea M.

AU - Wright, Julie K.

AU - Zhong, Kathleen

AU - Richard-Greenblatt, Melissa

AU - McDonald, Chloe R.

AU - Conroy, Andrea L.

AU - Namasopo, Sophie

AU - Opoka, Robert O.

AU - Hawkes, Michael

AU - Kain, Kevin C.

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Background: Current malaria diagnostic tests do not reliably identify children at risk of severe and fatal infection. Host immune and endothelial activation contribute to malaria pathogenesis. Soluble urokinase-Type plasminogen activator receptor (suPAR) is a marker of these pathways. We hypothesized that measuring suPAR at presentation could risk-stratify children with malaria. Methods: Plasma suPAR levels were determined in consecutive febrile children with malaria at presentation to hospital in Jinja, Uganda.

AB - Background: Current malaria diagnostic tests do not reliably identify children at risk of severe and fatal infection. Host immune and endothelial activation contribute to malaria pathogenesis. Soluble urokinase-Type plasminogen activator receptor (suPAR) is a marker of these pathways. We hypothesized that measuring suPAR at presentation could risk-stratify children with malaria. Methods: Plasma suPAR levels were determined in consecutive febrile children with malaria at presentation to hospital in Jinja, Uganda.

KW - mortality outcome

KW - prognostic marker

KW - risk-stratification

KW - severe malaria

KW - soluble urokinase-Type plasminogen activator receptor

UR - https://www.scopus.com/pages/publications/85147783656

U2 - 10.1093/cid/ciac457

DO - 10.1093/cid/ciac457

M3 - Article

C2 - 35675322

AN - SCOPUS:85147783656

SN - 1058-4838

VL - 76

SP - E1079-E1086

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 3

ER -

Soluble Urokinase-Type Plasminogen Activator Receptor as a Prognostic Marker of Ugandan Children at Risk of Severe and Fatal Malaria

Abstract

Keywords

UN SDGs

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