Stressor-induced alterations in serotonergic activity in an animal model of depression

Thomas J. Connor; Cai Song; Brian E. Leonard; Hymie Anisman; Zul Merali

doi:10.1097/00001756-199902250-00015

Stressor-induced alterations in serotonergic activity in an animal model of depression

Thomas J. Connor, Cai Song, Brian E. Leonard, Hymie Anisman, Zul Merali

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The present study examined the effect of two neurogenic stressors (air puff and restraint) and a metabolic stressor (lipopolysaccharide; LPS 100 μg/kg, i.p.) on accumbal serotonergic neurotransmission in the olfactory bulbectomized (OB) rat model of depression. Both air puff and restraint stress caused greater increases in accumbal 5-HIAA in OB than in sham- operated rats. In contrast, bulbectomy resulted in a blunted serotonergic response to a challenge with LPS (a metabolic stressor). In addition, OB rats displayed significantly lower basal levels of 5-HIAA than sham-operated counterparts, a finding consistent with previous reports of the OB rat being a model of hyposerotonergic depression. The relevance of these findings to stressor provoked depressive-like behaviors in the OB rat are discussed.

Original language	English
Pages (from-to)	523-528
Number of pages	6
Journal	NeuroReport
Volume	10
Issue number	3
DOIs	https://doi.org/10.1097/00001756-199902250-00015
Publication status	Published - 25 Feb 1999
Externally published	Yes

Keywords

Animal model
Depression
Nucleus accumbens
OB rat
Olfactory bulbectomy
Serotonin
Stress

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10.1097/00001756-199902250-00015

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abstract = "The present study examined the effect of two neurogenic stressors (air puff and restraint) and a metabolic stressor (lipopolysaccharide; LPS 100 μg/kg, i.p.) on accumbal serotonergic neurotransmission in the olfactory bulbectomized (OB) rat model of depression. Both air puff and restraint stress caused greater increases in accumbal 5-HIAA in OB than in sham- operated rats. In contrast, bulbectomy resulted in a blunted serotonergic response to a challenge with LPS (a metabolic stressor). In addition, OB rats displayed significantly lower basal levels of 5-HIAA than sham-operated counterparts, a finding consistent with previous reports of the OB rat being a model of hyposerotonergic depression. The relevance of these findings to stressor provoked depressive-like behaviors in the OB rat are discussed.",

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AU - Leonard, Brian E.

AU - Anisman, Hymie

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Stressor-induced alterations in serotonergic activity in an animal model of depression

Abstract

Keywords

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