Structural polymorphisms in fibrillar aggregates associated with exfoliation syndrome

Mehdi Ghaffari Sharaf, Sara Amidian, Vineet Rathod, Andrew Crichton, Karim F. Damji, Holger Wille, Larry D. Unsworth

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Exfoliation syndrome is largely considered an age-related disease that presents with fibrillar aggregates in the front part of the eye. A growing body of literature has investigated structural diversity of amyloids and fibrillar aggregates associated with neurodegenerative disease. However, in case of exfoliation syndrome, there is a dearth of information on the biophysical characteristics of these fibrils and structural polymorphisms. Herein, structural diversity of fibrils isolated from the anterior lens capsule of patients was evaluated using transmission electron microscopy techniques. It was apparent that, despite having a low sample number of different patients, there exists a wide range of fibril morphologies. As it is not precisely understood how these fibrils form, or what they are composed of, it is difficult to postulate a mechanism responsible for these differences in fibril structure. However, it is apparent that there is a wider range of fibril structure than initially appreciated. Moreover, these data may suggest the variance in fibril structure arises from patient-specific fibril composition and/or formation mechanisms.

Original languageEnglish
Article number15860
JournalScientific Reports
Issue number1
Publication statusPublished - 1 Dec 2020
Externally publishedYes


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