TY - JOUR
T1 - Studies on bronchodilator and cardiac stimulant activities of urginea indica
AU - Bashir, Samra
AU - Abbas, Saima
AU - Khan, Aslam
AU - Gilani, Anwar H.
N1 - Publisher Copyright:
© 2013, Bangladesh Pharmacological Society. All rights reserved.
PY - 2013
Y1 - 2013
N2 - This study was designed to evaluate bronchodilator and cardio-tonic effects of Urginea indica to provide rational for these medicinal uses. U. indica bulb extract was studied on rabbit tracheal and guinea-pig atrial preparations mounted in tissue baths under simulated physiological conditions. U. indica inhibited carbachol (1 µM) and K+ (80 mM)-induced contractions in rabbit trachea, similar to dicyclomine, suggesting the presence of anticholinergic and calcium channel blocking (CCB) mechanisms in U. indica. Anticholinergic and CCB effects of U. indica were respectively confirmed when it shifted the carbachol and Ca2+ concentration-response curves rightwards, similar to dicyclomine. U. indica (0.01-1 mg/mL) increased force of guinea-pig atrial contractions without significantly affecting the rate. These data, indicating that U. indica possesses the bronchodilator activity possibly mediated through a combination of anticholinergic and Ca2+ antagonist mechanisms together with selective positive inotropic effect, provide rational for medicinal applications of U. indica in airways and cardiac disorders.
AB - This study was designed to evaluate bronchodilator and cardio-tonic effects of Urginea indica to provide rational for these medicinal uses. U. indica bulb extract was studied on rabbit tracheal and guinea-pig atrial preparations mounted in tissue baths under simulated physiological conditions. U. indica inhibited carbachol (1 µM) and K+ (80 mM)-induced contractions in rabbit trachea, similar to dicyclomine, suggesting the presence of anticholinergic and calcium channel blocking (CCB) mechanisms in U. indica. Anticholinergic and CCB effects of U. indica were respectively confirmed when it shifted the carbachol and Ca2+ concentration-response curves rightwards, similar to dicyclomine. U. indica (0.01-1 mg/mL) increased force of guinea-pig atrial contractions without significantly affecting the rate. These data, indicating that U. indica possesses the bronchodilator activity possibly mediated through a combination of anticholinergic and Ca2+ antagonist mechanisms together with selective positive inotropic effect, provide rational for medicinal applications of U. indica in airways and cardiac disorders.
UR - http://www.scopus.com/inward/record.url?scp=84955491237&partnerID=8YFLogxK
U2 - 10.3329/bjp.v8i3.14825
DO - 10.3329/bjp.v8i3.14825
M3 - Article
AN - SCOPUS:84955491237
SN - 1991-007X
VL - 8
SP - 249
EP - 254
JO - Bangladesh Journal of Pharmacology
JF - Bangladesh Journal of Pharmacology
IS - 3
ER -