Subgroup stratified burden of hepatitis D virus in Asia

Huzefa Ahmed; Rida Ayub; Usama Ahmed; Bilal Ahmed; Afia Ayub; Adeel Masood; Erum Khan; Saeed Hamid

doi:10.12449/JCH260201

Subgroup stratified burden of hepatitis D virus in Asia

Huzefa Ahmed
, Rida Ayub
, Usama Ahmed
, Bilal Ahmed
, Afia Ayub
, Adeel Masood
, Erum Khan
, Saeed Hamid

Research output: Contribution to journal › Article › peer-review

Abstract

Hepatitis D virus（HDV）infection，the most severe form of viral hepatitis，remains underrecognized in the Asia due to inconsistent screening and limited surveillance. This systematic review（1970—2025）stratified HDV prevalence by population subgroups：community，hospital-based，and high-risk.Community studies showed high prevalence in Pakistan，Kazakhstan，and Kyrgyzstan；hospital cohorts revealed hyperendemicity in Mongolia and Uzbekistan；high-risk populations showed concentrated transmission in［Hong Kong，China］，［Taiwan，China］，Vietnam，and Sultanate of Oman. Many countries and regions lacked subgroup-specific data.The uneven，population-dependent burden underscores HDV as a major driver of advanced liver disease in Central and South Asia. Routine HDV screening and RNA-based diagnostics are essential to define burden and advance WHO 2030 elimination targets.

Original language	English (US)
Pages (from-to)	249-259
Number of pages	11
Journal	Journal of Clinical Hepatology
Volume	42
Issue number	2
DOIs	https://doi.org/10.12449/JCH260201
Publication status	Published - 2026

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Asia
Epidemiology
Hepatitis Delta Virus
δ 肝炎病毒
亚洲
流行病学

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10.12449/JCH260201

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title = "Subgroup stratified burden of hepatitis D virus in Asia",

abstract = "Hepatitis D virus（HDV）infection，the most severe form of viral hepatitis，remains underrecognized in the Asia due to inconsistent screening and limited surveillance. This systematic review（1970—2025）stratified HDV prevalence by population subgroups：community，hospital-based，and high-risk.Community studies showed high prevalence in Pakistan，Kazakhstan，and Kyrgyzstan；hospital cohorts revealed hyperendemicity in Mongolia and Uzbekistan；high-risk populations showed concentrated transmission in［Hong Kong，China］，［Taiwan，China］，Vietnam，and Sultanate of Oman. Many countries and regions lacked subgroup-specific data.The uneven，population-dependent burden underscores HDV as a major driver of advanced liver disease in Central and South Asia. Routine HDV screening and RNA-based diagnostics are essential to define burden and advance WHO 2030 elimination targets.",

keywords = "Asia, Epidemiology, Hepatitis Delta Virus, δ 肝炎病毒, 亚洲, 流行病学",

author = "Huzefa Ahmed and Rida Ayub and Usama Ahmed and Bilal Ahmed and Afia Ayub and Adeel Masood and Erum Khan and Saeed Hamid",

year = "2026",

doi = "10.12449/JCH260201",

language = "English (US)",

volume = "42",

pages = "249--259",

journal = "Journal of Clinical Hepatology",

issn = "1001-5256",

publisher = "Editorial Board of Jilin University",

number = "2",

}

TY - JOUR

T1 - Subgroup stratified burden of hepatitis D virus in Asia

AU - Ahmed, Huzefa

AU - Ayub, Rida

AU - Ahmed, Usama

AU - Ahmed, Bilal

AU - Ayub, Afia

AU - Masood, Adeel

AU - Khan, Erum

AU - Hamid, Saeed

PY - 2026

Y1 - 2026

N2 - Hepatitis D virus（HDV）infection，the most severe form of viral hepatitis，remains underrecognized in the Asia due to inconsistent screening and limited surveillance. This systematic review（1970—2025）stratified HDV prevalence by population subgroups：community，hospital-based，and high-risk.Community studies showed high prevalence in Pakistan，Kazakhstan，and Kyrgyzstan；hospital cohorts revealed hyperendemicity in Mongolia and Uzbekistan；high-risk populations showed concentrated transmission in［Hong Kong，China］，［Taiwan，China］，Vietnam，and Sultanate of Oman. Many countries and regions lacked subgroup-specific data.The uneven，population-dependent burden underscores HDV as a major driver of advanced liver disease in Central and South Asia. Routine HDV screening and RNA-based diagnostics are essential to define burden and advance WHO 2030 elimination targets.

AB - Hepatitis D virus（HDV）infection，the most severe form of viral hepatitis，remains underrecognized in the Asia due to inconsistent screening and limited surveillance. This systematic review（1970—2025）stratified HDV prevalence by population subgroups：community，hospital-based，and high-risk.Community studies showed high prevalence in Pakistan，Kazakhstan，and Kyrgyzstan；hospital cohorts revealed hyperendemicity in Mongolia and Uzbekistan；high-risk populations showed concentrated transmission in［Hong Kong，China］，［Taiwan，China］，Vietnam，and Sultanate of Oman. Many countries and regions lacked subgroup-specific data.The uneven，population-dependent burden underscores HDV as a major driver of advanced liver disease in Central and South Asia. Routine HDV screening and RNA-based diagnostics are essential to define burden and advance WHO 2030 elimination targets.

KW - Asia

KW - Epidemiology

KW - Hepatitis Delta Virus

KW - δ 肝炎病毒

KW - 亚洲

KW - 流行病学

UR - https://www.scopus.com/pages/publications/105038896315

U2 - 10.12449/JCH260201

DO - 10.12449/JCH260201

M3 - Article

AN - SCOPUS:105038896315

SN - 1001-5256

VL - 42

SP - 249

EP - 259

JO - Journal of Clinical Hepatology

JF - Journal of Clinical Hepatology

IS - 2

ER -

Subgroup stratified burden of hepatitis D virus in Asia

Abstract

UN SDGs

Keywords

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