TY - JOUR
T1 - 188Rhenium-glucoheptonate
T2 - A radiopharmaceutical for intravascular radiation therapy
AU - Pervez, S.
AU - Mushtaq, A.
AU - Arif, M.
AU - Chohan, Z. H.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - The preparation of 188Re-glucoheptonate (GH) is described using 188Re, which was obtained from an alumina based 188W/188Re generator. The dependence of the radiolabeling yields of 188Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-GH was ∼99%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of 188Re-GH was carried out in rats and compared to the biological behavior of 99mTc-GH.
AB - The preparation of 188Re-glucoheptonate (GH) is described using 188Re, which was obtained from an alumina based 188W/188Re generator. The dependence of the radiolabeling yields of 188Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-GH was ∼99%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of 188Re-GH was carried out in rats and compared to the biological behavior of 99mTc-GH.
UR - http://www.scopus.com/inward/record.url?scp=0038100322&partnerID=8YFLogxK
U2 - 10.1023/A:1023945603430
DO - 10.1023/A:1023945603430
M3 - Article
AN - SCOPUS:0038100322
SN - 0236-5731
VL - 256
SP - 293
EP - 296
JO - Journal of Radioanalytical and Nuclear Chemistry
JF - Journal of Radioanalytical and Nuclear Chemistry
IS - 2
ER -
