188Rhenium-glucoheptonate: A radiopharmaceutical for intravascular radiation therapy

S. Pervez; A. Mushtaq; M. Arif; Z. H. Chohan

doi:10.1023/A:1023945603430

¹⁸⁸Rhenium-glucoheptonate: A radiopharmaceutical for intravascular radiation therapy

S. Pervez
, A. Mushtaq
, M. Arif
, Z. H. Chohan

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The preparation of ¹⁸⁸Re-glucoheptonate (GH) is described using ¹⁸⁸Re, which was obtained from an alumina based ¹⁸⁸W/¹⁸⁸Re generator. The dependence of the radiolabeling yields of ¹⁸⁸Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of ¹⁸⁸Re-GH was ∼99%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of ¹⁸⁸Re-GH was carried out in rats and compared to the biological behavior of ^99mTc-GH.

Original language	English (US)
Pages (from-to)	293-296
Number of pages	4
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	256
Issue number	2
DOIs	https://doi.org/10.1023/A:1023945603430
Publication status	Published - 1 May 2003
Externally published	Yes

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SDG 3 Good Health and Well-being

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title = "188Rhenium-glucoheptonate: A radiopharmaceutical for intravascular radiation therapy",

abstract = "The preparation of 188Re-glucoheptonate (GH) is described using 188Re, which was obtained from an alumina based 188W/188Re generator. The dependence of the radiolabeling yields of 188Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-GH was ∼99\%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of 188Re-GH was carried out in rats and compared to the biological behavior of 99mTc-GH.",

author = "S. Pervez and A. Mushtaq and M. Arif and Chohan, \{Z. H.\}",

year = "2003",

month = may,

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doi = "10.1023/A:1023945603430",

language = "English (US)",

volume = "256",

pages = "293--296",

journal = "Journal of Radioanalytical and Nuclear Chemistry",

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number = "2",

}

TY - JOUR

T1 - 188Rhenium-glucoheptonate

T2 - A radiopharmaceutical for intravascular radiation therapy

AU - Pervez, S.

AU - Mushtaq, A.

AU - Arif, M.

AU - Chohan, Z. H.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - The preparation of 188Re-glucoheptonate (GH) is described using 188Re, which was obtained from an alumina based 188W/188Re generator. The dependence of the radiolabeling yields of 188Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-GH was ∼99%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of 188Re-GH was carried out in rats and compared to the biological behavior of 99mTc-GH.

AB - The preparation of 188Re-glucoheptonate (GH) is described using 188Re, which was obtained from an alumina based 188W/188Re generator. The dependence of the radiolabeling yields of 188Re-GH on reducing agent concentration, GH concentration, pH, temperature and incubation time was examined. In the case of optimum conditions the yield of 188Re-GH was ∼99%. The ITLC technique was employed to monitor the different species formed. A biodistribution study of 188Re-GH was carried out in rats and compared to the biological behavior of 99mTc-GH.

UR - https://www.scopus.com/pages/publications/0038100322

U2 - 10.1023/A:1023945603430

DO - 10.1023/A:1023945603430

M3 - Article

AN - SCOPUS:0038100322

SN - 0236-5731

VL - 256

SP - 293

EP - 296

JO - Journal of Radioanalytical and Nuclear Chemistry

JF - Journal of Radioanalytical and Nuclear Chemistry

IS - 2

ER -

¹⁸⁸Rhenium-glucoheptonate: A radiopharmaceutical for intravascular radiation therapy

Abstract

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