TY - JOUR
T1 - Superbugs causing ventilator associated pneumonia in a tertiary care hospital and the return of pre-antibiotic era!
AU - Qureshi, S.
AU - Agrawal, C.
AU - Madan, M.
AU - Pandey, A.
AU - Chauhan, H.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - The rise in super bugs causing Ventilator-Associated Pneumonia (VAP) is a major cause of mortality and morbidity despite recent advances in management owing to the looming 'antibiotic apocalypse'. The aetiology and susceptibility pattern of the VAP isolates varies with patient population, type of intensive care unit (ICU) and is an urgent diagnostic challenge. The present study carried out for a period of one year in a tertiary care hospital, enrolled patients on mechanical ventilation (MV) for ≥48 hrs. Endotracheal aspirates (ETA) from suspected VAP patients were processed by semi quantitative method. Staphylococus aureus, members of Enterobacteriaceae were more common in early onset VAP (EOVAP), while Nonfermenting Gram negative bacilli (NFGNB) were significantly associated with late onset VAP (LOVAP). Most of the isolates were multi drug resistant (MDR) super bugs. With limited treatment options left for this crisis situation like the pre-antibiotic era; it is an alarm for rational antibiotic therapy usage and intensive education programs.
AB - The rise in super bugs causing Ventilator-Associated Pneumonia (VAP) is a major cause of mortality and morbidity despite recent advances in management owing to the looming 'antibiotic apocalypse'. The aetiology and susceptibility pattern of the VAP isolates varies with patient population, type of intensive care unit (ICU) and is an urgent diagnostic challenge. The present study carried out for a period of one year in a tertiary care hospital, enrolled patients on mechanical ventilation (MV) for ≥48 hrs. Endotracheal aspirates (ETA) from suspected VAP patients were processed by semi quantitative method. Staphylococus aureus, members of Enterobacteriaceae were more common in early onset VAP (EOVAP), while Nonfermenting Gram negative bacilli (NFGNB) were significantly associated with late onset VAP (LOVAP). Most of the isolates were multi drug resistant (MDR) super bugs. With limited treatment options left for this crisis situation like the pre-antibiotic era; it is an alarm for rational antibiotic therapy usage and intensive education programs.
KW - Endotracheal aspirate
KW - non fermenting gram negative bacilli
KW - superbugs
KW - ventilator associated pneumonia
UR - http://www.scopus.com/inward/record.url?scp=84928562199&partnerID=8YFLogxK
U2 - 10.4103/0255-0857.153566
DO - 10.4103/0255-0857.153566
M3 - Article
C2 - 25865985
AN - SCOPUS:84928562199
SN - 0255-0857
VL - 33
SP - 286
EP - 289
JO - Indian Journal of Medical Microbiology
JF - Indian Journal of Medical Microbiology
IS - 2
ER -
