Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis

Kiran I. Masood; Shahid Pervez; Martin E. Rottenberg; Beena Umar; Zahra Hasan

doi:10.1016/j.jmii.2015.08.018

Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis

Kiran I. Masood
, Shahid Pervez
, Martin E. Rottenberg
, Beena Umar
, Zahra Hasan

Department of Pathology and Laboratory Medicine, Medical College, Pakistan

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.

Original language	English (US)
Pages (from-to)	984-987
Number of pages	4
Journal	Journal of Microbiology, Immunology and Infection
Volume	49
Issue number	6
DOIs	https://doi.org/10.1016/j.jmii.2015.08.018
Publication status	Published - 1 Dec 2016

Keywords

caseous necrosis
granuloma
suppressor of cytokine signaling-1
tuberculous lymphadenitis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jmii.2015.08.018

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title = "Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis",

abstract = "We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.",

keywords = "caseous necrosis, granuloma, suppressor of cytokine signaling-1, tuberculous lymphadenitis",

author = "Masood, \{Kiran I.\} and Shahid Pervez and Rottenberg, \{Martin E.\} and Beena Umar and Zahra Hasan",

note = "Publisher Copyright: {\textcopyright} 2015",

year = "2016",

month = dec,

day = "1",

doi = "10.1016/j.jmii.2015.08.018",

language = "English (US)",

volume = "49",

pages = "984--987",

journal = "Journal of Microbiology, Immunology and Infection",

issn = "1684-1182",

publisher = "Elsevier Ltd.",

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}

Masood, KI , Pervez, S, Rottenberg, ME, Umar, B & Hasan, Z 2016, 'Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis', Journal of Microbiology, Immunology and Infection, vol. 49, no. 6, pp. 984-987. https://doi.org/10.1016/j.jmii.2015.08.018

Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis. / Masood, Kiran I.; Pervez, Shahid; Rottenberg, Martin E. et al.
In: Journal of Microbiology, Immunology and Infection, Vol. 49, No. 6, 01.12.2016, p. 984-987.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis

AU - Masood, Kiran I.

AU - Pervez, Shahid

AU - Rottenberg, Martin E.

AU - Umar, Beena

AU - Hasan, Zahra

PY - 2016/12/1

Y1 - 2016/12/1

N2 - We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.

AB - We investigated the role of suppressor of cytokine signaling-1 (SOCS1) and SOCS3 molecules in lymph nodes from tuberculous lymphadenitis patients (LNTB). Fewer T cells were noted in LNTB cases, which also had raised chemokine (C-X-C motif) receptor 3 (CXCR3) levels. In addition, we observed a positive correlation between CXCR3 and SOCS1 expression. Our data suggest that upregulation of SOCS1 molecules may contribute to the dissemination of Mycobacterium tuberculosis from granulomas.

KW - caseous necrosis

KW - granuloma

KW - suppressor of cytokine signaling-1

KW - tuberculous lymphadenitis

UR - https://www.scopus.com/pages/publications/85006213915

U2 - 10.1016/j.jmii.2015.08.018

DO - 10.1016/j.jmii.2015.08.018

M3 - Article

C2 - 26455487

AN - SCOPUS:85006213915

SN - 1684-1182

VL - 49

SP - 984

EP - 987

JO - Journal of Microbiology, Immunology and Infection

JF - Journal of Microbiology, Immunology and Infection

IS - 6

ER -

Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis

Abstract

Keywords

UN SDGs

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