Synchronous and metachronous malignant epithelial and lymphoid tumors: A clinicopathologic study of 10 patients from a major tertiary care center in Pakistan

Nasir Ud Din, Zubair Ahmad, Khurram Minhas, Zeeshan Uddin, Arsalan Ahmed

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Case reports and case series documenting unfortunate patients with more than one malignant neoplasm are rare but well established. While majority of such patients have two malignancies, cases with three or even four malignant neoplasms in the same patient have been published in literature. A number of factors influencing carcinogenesis have been implicated in such cases including exposure to large amounts of radiation, chemotherapy for the original malignancy; prolonged history of heavy smoking and exposure to other environmental carcinogens; aging; and underlying genetic alterations. Concomitant multiple malignant neoplasms may be synchronous-two or more malignant neoplasms histologically distinct from each other, arising in the same site and detected simultaneously (for example during the same hospital admission) or detected one after the other in sequence in a period less than 6 months; or metachronous-two or more malignant neoplasms of similar or distinct histologic type detected at different times (after an interval of greater than 6 months) in different anatomic sites. Any combination of malignant tumors can occur in the same patient for example carcinomas with other carcinomas, carcinomas with Non-Hodgkin or Hodgkin lymphomas, carcinomas with mesotheliomas, carcinomas with sarcomas etc. We have reported several cases with multiple malignancies during our practice, and these cases were composed of the different combinations described above. The aim of the present study is to document 10 such cases of combined carcinoma and Non Hodgkin lymphoma in the same patient which were diagnosed in our section.

Original languageEnglish
Pages (from-to)2067-2072
Number of pages6
JournalAsian Pacific Journal of Cancer Prevention
Volume18
Issue number8
DOIs
Publication statusPublished - 1 Aug 2017

Keywords

  • Carcinoma
  • Concomitant
  • Lymphoma
  • Malignancy
  • Metachronous
  • Synchronous

Fingerprint

Dive into the research topics of 'Synchronous and metachronous malignant epithelial and lymphoid tumors: A clinicopathologic study of 10 patients from a major tertiary care center in Pakistan'. Together they form a unique fingerprint.

Cite this