Synthesis, spectral characterization and biological evaluation of organotin(IV) complexes of aniline derivatives of naturally occurring betulinic acid

Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer, antiviral, antimalarial, antifungal, antioxidant and antiprotozoal agents. Cis-platin (cytotoxic agent) has diverted attention of chemists towards organotin complexes with marked pharmacological activities. In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. These complexes were characterized by FT-IR and multinuclear NMR (¹H and ¹³C) spectroscopy. The ligands and their organotin(IV) complexes were screened for antibacterial, antifungal and antioxidant activities. Compound L² ₂SnMe₂ was found with maximum antibacterial activity among the screened compounds. Compounds L¹ ₂SnMe₂ and L¹ ₂SnPh₂ were found with remarkable antifungal activity. Similarly L¹, L¹ ₂SnBu₂, L² and L² ₂SnMe₃ were remarked with good antioxidant activity.