Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate

Wajid Rehman; Amin Badshah; Fazal Rahim; Musa Kaleem Baloch; Hameed Ullah; Obaid Ur Rahman Abid; Mohsan Nawaz; Isfahan Tauseef

doi:10.1016/j.ica.2014.08.006

Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate

Wajid Rehman, Amin Badshah, Fazal Rahim, Musa Kaleem Baloch, Hameed Ullah, Obaid Ur Rahman Abid, Mohsan Nawaz, Isfahan Tauseef

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

A novel series of diorganotin(IV) complexes of the type R₂SnL₂ (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, ¹H, ¹³C, ¹¹⁹Sn NMR, ^119mSn Mössbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity.

Original language	English (UK)
Pages (from-to)	177-182
Number of pages	6
Journal	Inorganica Chimica Acta
Volume	423
Issue number	PB
DOIs	https://doi.org/10.1016/j.ica.2014.08.006
Publication status	Published - 1 Nov 2014
Externally published	Yes

Keywords

2-Phenylmonomethylglutarate
Antibacterial
Antitumor
Organotin(IV)

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10.1016/j.ica.2014.08.006

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@article{daa523f140a94cfc969ad9d30c5e9fc9,

title = "Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate",

abstract = "A novel series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, 1H, 13C, 119Sn NMR, 119mSn M{\"o}ssbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity.",

keywords = "2-Phenylmonomethylglutarate, Antibacterial, Antitumor, Organotin(IV)",

author = "Wajid Rehman and Amin Badshah and Fazal Rahim and Baloch, \{Musa Kaleem\} and Hameed Ullah and Abid, \{Obaid Ur Rahman\} and Mohsan Nawaz and Isfahan Tauseef",

year = "2014",

month = nov,

day = "1",

doi = "10.1016/j.ica.2014.08.006",

language = "English (UK)",

volume = "423",

pages = "177--182",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier BV",

number = "PB",

}

TY - JOUR

T1 - Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate

AU - Rehman, Wajid

AU - Badshah, Amin

AU - Rahim, Fazal

AU - Baloch, Musa Kaleem

AU - Ullah, Hameed

AU - Abid, Obaid Ur Rahman

AU - Nawaz, Mohsan

AU - Tauseef, Isfahan

PY - 2014/11/1

Y1 - 2014/11/1

N2 - A novel series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, 1H, 13C, 119Sn NMR, 119mSn Mössbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity.

AB - A novel series of diorganotin(IV) complexes of the type R2SnL2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylmonomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, 1H, 13C, 119Sn NMR, 119mSn Mössbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity.

KW - 2-Phenylmonomethylglutarate

KW - Antibacterial

KW - Antitumor

KW - Organotin(IV)

UR - https://www.scopus.com/pages/publications/84910131346

U2 - 10.1016/j.ica.2014.08.006

DO - 10.1016/j.ica.2014.08.006

M3 - Article

AN - SCOPUS:84910131346

SN - 0020-1693

VL - 423

SP - 177

EP - 182

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

IS - PB

ER -

Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate

Abstract

Keywords

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