T(1:14) and trisomy 4 in a patient with concomitant leukaemias

Muhammad Nauman Zahir, Nehal Masood, Munira Shabbir-Moosajee

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Cytogenetic abnormalities have long been recognized as the genetic basis of the occurrence of various malignancies. Specific cytogenetic abnormalities have shown to occur recurrently in particular subtypes of leukaemias and lymphomas. t(1;14) is an infrequently occurring recurrent chromosomal translocation that has been described in literature to be associated with haematological malignancies. Trisomy 4 is another rare genetic abnormality which has been reported in association with both acute myeloid and lymphoid leukaemias. The concomitant occurrence of a myeloid malignancy in association with a lymphoproliferative disorder is a distinctly unusual phenomenon. We report the case of a young patient with concomitant T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia with a novel cytogenetic abnormality i.e. t(1;14) with trisomy 4. We believe this is the first reported case where a patient with two concomitant haematological malignancies, harboured this karyotype.

Original languageEnglish
Pages (from-to)596-598
Number of pages3
JournalJournal of the Pakistan Medical Association
Issue number5
Publication statusPublished - May 2014


  • Acute myeloid leukaemia lymphoproliferative disorders
  • Chromosomal translocations
  • Karyotype
  • Trisomy


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