Targeting Inflammation After Myocardial Infarction

Dhruv Mahtta, Deepthi Sudhakar, Srikanth Koneru, Guilherme Vianna Silva, Mahboob Alam, Salim S. Virani, Hani Jneid

Research output: Contribution to journalReview articlepeer-review

23 Citations (Scopus)

Abstract

Purpose of Review: Inflammation plays a key role in clearing cellular debris and recovery after acute myocardial infarction (AMI). Dysregulation of or prolonged inflammation may result in adverse cardiac remodeling and major adverse clinical events (MACE). Several pre-clinical studies and moderate sized clinical trials have investigated the role of immunomodulation in improving clinical outcomes in patients with AMI. Recent Findings: Clinical data from the Canakinumab Atherothrombosis Outcome (CANTOS) and Colchicine Cardiovascular Outcomes Trial (COLCOT) have provided encouraging results among patients with AMI. Several other clinical and pre-clinical trials have brought about the prospect of modulating inflammation at various junctures of the inflammatory cascade including inhibition of complement cascade, interleukins, and matrix metalloproteinases. Summary: In patients with AMI, modulation of residual inflammation via various inflammatory pathways and mediators may hold promise for further reducing MACE. Learning from current data and understanding the nuances of immunomodulation in AMI are key for future trials and before widespread dissemination of such therapies.

Original languageEnglish
Article number110
JournalCurrent Cardiology Reports
Volume22
Issue number10
DOIs
Publication statusPublished - 1 Oct 2020
Externally publishedYes

Keywords

  • Anti-inflammatory
  • Cardiac remodeling
  • Immunomodulation
  • Inflammation
  • Myocardial infarction

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