TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines

Lai San Siu; Hanna Romanska; Paul D. Abel; Mirela Baus-Loncar; Tuncay Kayademir; Gordon W.H. Stamp; El Nasir Lalani

doi:10.1016/j.peptides.2003.11.023

TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines

Lai San Siu, Hanna Romanska, Paul D. Abel, Mirela Baus-Loncar, Tuncay Kayademir, Gordon W.H. Stamp, El Nasir Lalani

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2-) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2-) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression.

Original language	English
Pages (from-to)	855-863
Number of pages	9
Journal	Peptides
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/j.peptides.2003.11.023
Publication status	Published - May 2004
Externally published	Yes

Keywords

Adenocarcinoma
Cytoprotection
TFF2

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.peptides.2003.11.023

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@article{687e1945159848e1b786e486ce908d6d,

title = "TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines",

abstract = "We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2-) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2-) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression.",

keywords = "Adenocarcinoma, Cytoprotection, TFF2",

author = "Siu, {Lai San} and Hanna Romanska and Abel, {Paul D.} and Mirela Baus-Loncar and Tuncay Kayademir and Stamp, {Gordon W.H.} and Lalani, {El Nasir}",

year = "2004",

month = may,

doi = "10.1016/j.peptides.2003.11.023",

language = "English",

volume = "25",

pages = "855--863",

journal = "Peptides",

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publisher = "Elsevier Inc.",

number = "5",

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T1 - TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines

AU - Siu, Lai San

AU - Romanska, Hanna

AU - Abel, Paul D.

AU - Baus-Loncar, Mirela

AU - Kayademir, Tuncay

AU - Stamp, Gordon W.H.

AU - Lalani, El Nasir

PY - 2004/5

Y1 - 2004/5

N2 - We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2-) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2-) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression.

AB - We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2-) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2-) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression.

KW - Adenocarcinoma

KW - Cytoprotection

KW - TFF2

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U2 - 10.1016/j.peptides.2003.11.023

DO - 10.1016/j.peptides.2003.11.023

M3 - Article

C2 - 15177882

AN - SCOPUS:2642545563

SN - 0196-9781

VL - 25

SP - 855

EP - 863

JO - Peptides

JF - Peptides

IS - 5

ER -

TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines

Abstract

Keywords

UN SDGs

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