The antibiofilm activity of Acetylsalicylic acid, Mefenamic acid, Acetaminophen against biofilms formed by P. aeruginosa and S. epidermidis

Syed Hani Abidi, Khalid Ahmed, Shahana Urooj Kazmi

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the antibacterial activity of Aspirin, Mefenamic acid and Acetaminophen against Pseudomonas aeruginosa and Staphylococcus epidermidis biofilms. METHODS: The study was conducted AKU Karachi in collaboration with DIHE Karachi from March 2018 to December 2018.Quantitative spectrophotometric method was used to study the reduction and removal of the Pseudomonas aeruginosa and Staphylococcus epidermidis formed biofilms. Statistical tests were performed using Graph Pad Prism software. . RESULTS: Acetaminophen showed maximum biofilm reduction activity against the biofilms formed by Pseudomonas aeruginosa, and Staphylococcus epidermidis. Mefanamic acid showed maximum biofilm removal potential against Pseudomonas aeruginosa, while Aspirin and Mefanamic acid were equally effective in removing biofilms formed by Staphylococcus epidermidis as well. CONCLUSIONS: There is a continuous need to look for non-antibiotic agents for their potential antimicrobial and antibiofilm potential.

Original languageEnglish
Pages (from-to)1493-1495
Number of pages3
JournalJPMA. The Journal of the Pakistan Medical Association
Volume69
Issue number10
DOIs
Publication statusPublished - 1 Oct 2019

Keywords

  • Antibiofilm activity, Aspirin, Mefenamic acid, Acetaminophen, P. aeruginosa, S. epidermidis biofilms. (JPMA 69: 1493; 2019).doi:10.5455/JPMA.295488

Fingerprint

Dive into the research topics of 'The antibiofilm activity of Acetylsalicylic acid, Mefenamic acid, Acetaminophen against biofilms formed by P. aeruginosa and S. epidermidis'. Together they form a unique fingerprint.

Cite this