The continuing burden of Rh disease 50 years after the introduction of anti-Rh(D) immunoglobin prophylaxis: call to action

FIGO Committee Safe Motherhood and Newborn Health

doi:10.1016/j.ajog.2019.05.019

The continuing burden of Rh disease 50 years after the introduction of anti-Rh(D) immunoglobin prophylaxis: call to action

FIGO Committee Safe Motherhood and Newborn Health

School of Nursing & Midwifery, Pakistan

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Severe morbidity and death because of Rh disease have only been reduced by approximately 50% globally during the last 50 years, despite the advent of anti-Rh(D) immunoglobin prophylaxis, which has resulted in >160,000 perinatal deaths and 100,000 disabilities annually. This apparent failure to take appropriate preventive measures is of great concern. Thus, there is a great need to do much better. We wish to draw attention to the unnecessary continuing burden of Rh disease, to discuss some of the reasons for this failure, and to provide suggestions for a better way forward.

Original language	English
Pages (from-to)	227.e1-227.e4
Journal	American Journal of Obstetrics and Gynecology
Volume	221
Issue number	3
DOIs	https://doi.org/10.1016/j.ajog.2019.05.019
Publication status	Published - Sept 2019

Keywords

alloimmunization
blood groups
fetal anemia
hemolysis
hemolytic disease of the fetus and newborn
hyperbilirubinemia
isoimmunization
prevention
Rh disease

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10.1016/j.ajog.2019.05.019

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title = "The continuing burden of Rh disease 50 years after the introduction of anti-Rh(D) immunoglobin prophylaxis: call to action",

abstract = "Severe morbidity and death because of Rh disease have only been reduced by approximately 50% globally during the last 50 years, despite the advent of anti-Rh(D) immunoglobin prophylaxis, which has resulted in >160,000 perinatal deaths and 100,000 disabilities annually. This apparent failure to take appropriate preventive measures is of great concern. Thus, there is a great need to do much better. We wish to draw attention to the unnecessary continuing burden of Rh disease, to discuss some of the reasons for this failure, and to provide suggestions for a better way forward.",

keywords = "alloimmunization, blood groups, fetal anemia, hemolysis, hemolytic disease of the fetus and newborn, hyperbilirubinemia, isoimmunization, prevention, Rh disease",

author = "{FIGO Committee Safe Motherhood and Newborn Health} and Visser, {Gerard H.A.} and {Di Renzo}, {Gian Carlo} and Spitalnik, {Steven L.} and Diogo Ayres-de-Campos and {Fernanda Escobar}, Maria and Eytan Barnea and Shah, {P. K.} and Anwar Nasser and {de Bernis}, Luc and Luming Sun and {Kay Nicholson}, Wanda and Isabel Lloyd and Salimah Walani and Gerhard Theron and William Stones",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

doi = "10.1016/j.ajog.2019.05.019",

language = "English",

volume = "221",

pages = "227.e1--227.e4",

journal = "American Journal of Obstetrics and Gynecology",

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T1 - The continuing burden of Rh disease 50 years after the introduction of anti-Rh(D) immunoglobin prophylaxis

T2 - call to action

AU - FIGO Committee Safe Motherhood and Newborn Health

AU - Visser, Gerard H.A.

AU - Di Renzo, Gian Carlo

AU - Spitalnik, Steven L.

AU - Ayres-de-Campos, Diogo

AU - Fernanda Escobar, Maria

AU - Barnea, Eytan

AU - Shah, P. K.

AU - Nasser, Anwar

AU - de Bernis, Luc

AU - Sun, Luming

AU - Kay Nicholson, Wanda

AU - Lloyd, Isabel

AU - Walani, Salimah

AU - Theron, Gerhard

AU - Stones, William

PY - 2019/9

Y1 - 2019/9

N2 - Severe morbidity and death because of Rh disease have only been reduced by approximately 50% globally during the last 50 years, despite the advent of anti-Rh(D) immunoglobin prophylaxis, which has resulted in >160,000 perinatal deaths and 100,000 disabilities annually. This apparent failure to take appropriate preventive measures is of great concern. Thus, there is a great need to do much better. We wish to draw attention to the unnecessary continuing burden of Rh disease, to discuss some of the reasons for this failure, and to provide suggestions for a better way forward.

AB - Severe morbidity and death because of Rh disease have only been reduced by approximately 50% globally during the last 50 years, despite the advent of anti-Rh(D) immunoglobin prophylaxis, which has resulted in >160,000 perinatal deaths and 100,000 disabilities annually. This apparent failure to take appropriate preventive measures is of great concern. Thus, there is a great need to do much better. We wish to draw attention to the unnecessary continuing burden of Rh disease, to discuss some of the reasons for this failure, and to provide suggestions for a better way forward.

KW - alloimmunization

KW - blood groups

KW - fetal anemia

KW - hemolysis

KW - hemolytic disease of the fetus and newborn

KW - hyperbilirubinemia

KW - isoimmunization

KW - prevention

KW - Rh disease

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U2 - 10.1016/j.ajog.2019.05.019

DO - 10.1016/j.ajog.2019.05.019

M3 - Article

C2 - 31121145

AN - SCOPUS:85068269075

SN - 0002-9378

VL - 221

SP - 227.e1-227.e4

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

IS - 3

ER -

The continuing burden of Rh disease 50 years after the introduction of anti-Rh(D) immunoglobin prophylaxis: call to action

Abstract

Keywords

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