TY - JOUR
T1 - The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs
AU - Yakoob, Javed
AU - Jafri, Wasim
AU - Abbas, Zaigham
AU - Abid, Shahab
AU - Islam, Muhammad
AU - Ahmed, Zubair
N1 - Funding Information:
Acknowledgements This work was supported by the Aga Khan University Research Grant SM 100 327*11 431 to JY. The authors are grateful to Mr. Loay Lubbad and other staff members at the Juma Research Building, Aga Khan University for their assistance during this work.
PY - 2008/1
Y1 - 2008/1
N2 - The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs, such as proton pump inhibitors (PPI) and histamine-2 receptor blocker (H2RB), was compared. Seventy-four consecutive patients on acid-reducing drugs were enrolled: 34 (46%) were on PPIs, 20 (27%) were on H2RBs and 20 (27%) were not on medications. For those patients on PPIs, RUT and histology results from antrum were negative in 28 (82%) and 17 (50%) patients, respectively (OR: 4.7; 95% CI: 1.4-16.6; P = 0.004), while those from the corpus were negative in was 28 (82%) and 18 (53%) patients, respectively (OR: 4.4, 95% CI: 1.3-15.5; P = 0.006). For patients on H2RBs, RUT and histology results from the antrum were negative in 12 (60%) and six (30%) patients, respectively (OR: 3.5; 95% CI: 0.8-16.1; P = 0.05), while those from the corpus were negative in 12 (60%) and nine (45%) patients, respectively (OR: 1.8; 95% CI: 0.4-7.8; P = 0.342). For those patients on PPIs, the diagnostic yield of both RUT and histology was reduced from both the antrum and corpus. In these patients, PCR for H. pylori is more sensitive than RUT and histology.
AB - The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs, such as proton pump inhibitors (PPI) and histamine-2 receptor blocker (H2RB), was compared. Seventy-four consecutive patients on acid-reducing drugs were enrolled: 34 (46%) were on PPIs, 20 (27%) were on H2RBs and 20 (27%) were not on medications. For those patients on PPIs, RUT and histology results from antrum were negative in 28 (82%) and 17 (50%) patients, respectively (OR: 4.7; 95% CI: 1.4-16.6; P = 0.004), while those from the corpus were negative in was 28 (82%) and 18 (53%) patients, respectively (OR: 4.4, 95% CI: 1.3-15.5; P = 0.006). For patients on H2RBs, RUT and histology results from the antrum were negative in 12 (60%) and six (30%) patients, respectively (OR: 3.5; 95% CI: 0.8-16.1; P = 0.05), while those from the corpus were negative in 12 (60%) and nine (45%) patients, respectively (OR: 1.8; 95% CI: 0.4-7.8; P = 0.342). For those patients on PPIs, the diagnostic yield of both RUT and histology was reduced from both the antrum and corpus. In these patients, PCR for H. pylori is more sensitive than RUT and histology.
KW - H. pylori infection
KW - Histamine2 receptor blocker
KW - Histology
KW - Proton pump inhibitor
KW - Rapid urease test
UR - http://www.scopus.com/inward/record.url?scp=37249075441&partnerID=8YFLogxK
U2 - 10.1007/s10620-007-9828-y
DO - 10.1007/s10620-007-9828-y
M3 - Article
C2 - 17497222
AN - SCOPUS:37249075441
SN - 0163-2116
VL - 53
SP - 95
EP - 100
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 1
ER -