TY - JOUR
T1 - The Effect of Cytotoxic and Anti‐inflammatory Drugs on the Phagocytosis of Neutrophil Leucocytes
AU - Whittaker, J. A.
AU - Hughes, H. R.
AU - Khurshid, M.
PY - 1975/2
Y1 - 1975/2
N2 - Summary. The phagocytosis of heat‐killed Candida albicans by neutrophil leucocytes was inhibited in vitro by phenylbutazone and acctylsalicylic acid and by the cytotoxic drugs vincristine, vinblastine, cytosinc arabinoside, daunorubicin and busulphan, but not by mustinc hydrochloride or procarbazine. In vivo studies in man have shown a significant reduction in phagocytosis after phenylbutazone ingestion, but not following an oral dose of aspirin. Possible explanatory mechanisms of drug action on neutrophil phagocytosis are discussed.
AB - Summary. The phagocytosis of heat‐killed Candida albicans by neutrophil leucocytes was inhibited in vitro by phenylbutazone and acctylsalicylic acid and by the cytotoxic drugs vincristine, vinblastine, cytosinc arabinoside, daunorubicin and busulphan, but not by mustinc hydrochloride or procarbazine. In vivo studies in man have shown a significant reduction in phagocytosis after phenylbutazone ingestion, but not following an oral dose of aspirin. Possible explanatory mechanisms of drug action on neutrophil phagocytosis are discussed.
UR - http://www.scopus.com/inward/record.url?scp=0016609276&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.1975.tb01821.x
DO - 10.1111/j.1365-2141.1975.tb01821.x
M3 - Article
C2 - 1191548
AN - SCOPUS:0016609276
SN - 0007-1048
VL - 29
SP - 273
EP - 278
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 2
ER -