The Effect of Cytotoxic and Anti‐inflammatory Drugs on the Phagocytosis of Neutrophil Leucocytes

J. A. Whittaker; H. R. Hughes; M. Khurshid

doi:10.1111/j.1365-2141.1975.tb01821.x

The Effect of Cytotoxic and Anti‐inflammatory Drugs on the Phagocytosis of Neutrophil Leucocytes

J. A. Whittaker, H. R. Hughes, M. Khurshid

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Summary. The phagocytosis of heat‐killed Candida albicans by neutrophil leucocytes was inhibited in vitro by phenylbutazone and acctylsalicylic acid and by the cytotoxic drugs vincristine, vinblastine, cytosinc arabinoside, daunorubicin and busulphan, but not by mustinc hydrochloride or procarbazine. In vivo studies in man have shown a significant reduction in phagocytosis after phenylbutazone ingestion, but not following an oral dose of aspirin. Possible explanatory mechanisms of drug action on neutrophil phagocytosis are discussed.

Original language	English (UK)
Pages (from-to)	273-278
Number of pages	6
Journal	British Journal of Haematology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2141.1975.tb01821.x
Publication status	Published - Feb 1975
Externally published	Yes

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10.1111/j.1365-2141.1975.tb01821.x

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abstract = "Summary. The phagocytosis of heat‐killed Candida albicans by neutrophil leucocytes was inhibited in vitro by phenylbutazone and acctylsalicylic acid and by the cytotoxic drugs vincristine, vinblastine, cytosinc arabinoside, daunorubicin and busulphan, but not by mustinc hydrochloride or procarbazine. In vivo studies in man have shown a significant reduction in phagocytosis after phenylbutazone ingestion, but not following an oral dose of aspirin. Possible explanatory mechanisms of drug action on neutrophil phagocytosis are discussed.",

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N2 - Summary. The phagocytosis of heat‐killed Candida albicans by neutrophil leucocytes was inhibited in vitro by phenylbutazone and acctylsalicylic acid and by the cytotoxic drugs vincristine, vinblastine, cytosinc arabinoside, daunorubicin and busulphan, but not by mustinc hydrochloride or procarbazine. In vivo studies in man have shown a significant reduction in phagocytosis after phenylbutazone ingestion, but not following an oral dose of aspirin. Possible explanatory mechanisms of drug action on neutrophil phagocytosis are discussed.

AB - Summary. The phagocytosis of heat‐killed Candida albicans by neutrophil leucocytes was inhibited in vitro by phenylbutazone and acctylsalicylic acid and by the cytotoxic drugs vincristine, vinblastine, cytosinc arabinoside, daunorubicin and busulphan, but not by mustinc hydrochloride or procarbazine. In vivo studies in man have shown a significant reduction in phagocytosis after phenylbutazone ingestion, but not following an oral dose of aspirin. Possible explanatory mechanisms of drug action on neutrophil phagocytosis are discussed.

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U2 - 10.1111/j.1365-2141.1975.tb01821.x

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The Effect of Cytotoxic and Anti‐inflammatory Drugs on the Phagocytosis of Neutrophil Leucocytes

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