The effects of non-steroidal anti-inflammatory drugs on the disposition of methotrexate in patients with rheumatoid arthritis

M. Perwaiz Iqbal, Javed A. Baig, Azra A. Ali, Sarfaraz K. Niazi, N. Mehboobali, M. Azmat Hussain

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31 Citations (Scopus)

Abstract

We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently taking the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, diclofenac, naproxen, indomethacin, and ibuprofen. The area under the curve, the total systemic clearance, the distribution volume, and the half-life of methotrexate in patients receiving concurrent NSAID therapy did not change significantly (at p < 0.05). Concurrent treatment with NSAIDs resulted in increased inter-patient variability of methotrexate concentration, possibly as a result of biochemical interactions; however, it does not appear clinically relevant. The data suggest that the NSAIDs do not significantly affect the disposition of methotrexate, contrary to some of the earlier reports.

Original languageEnglish
Pages (from-to)163-167
Number of pages5
JournalBiopharmaceutics and Drug Disposition
Volume19
Issue number3
DOIs
Publication statusPublished - 1998

Keywords

  • Adverse effects
  • Disposition
  • Interaction
  • Methotrexate
  • Non-steroidal inflammatory drugs (NSAIDs)
  • Pharmacokinetics

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