TY - JOUR
T1 - The emergence of an unassigned complex recombinant form in a Pakistani HIV-infected individual
AU - Tariq, Uroosa
AU - Iftikhar, Ayesha
AU - Zahid, Dilsha
AU - Sultan, Faisal
AU - Mahmood, Syed Faisal
AU - Naeem, Sadaf
AU - Ali, Syed
AU - Abidi, Syed Hani
N1 - Funding Information:
This research was funded by Aga Khan University Seed Money Grant PF84/0716; Higher Education Commission, Pakistan Grant 5217/Sindh/NRPU/R&D/HEC/2016; and Pakistan Science Foundation Grant PSF/Res/S-AKU/Med (488).
Publisher Copyright:
© 2020, Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2020/4/1
Y1 - 2020/4/1
N2 - In Pakistan, the HIV situation has gone from an outbreak to a concentrated epidemic, and the virus has now crossed into the low-risk population. In addition, several new HIV outbreaks have occurred in different parts of the country. HIV-1 subtype A has been the major epidemic subtype in Pakistan; however, as the epidemic has grown, the emergence of several new subtypes and recombinant forms has been observed. Here, we present the first case and genetic analysis of an unassigned, complex recombinant form in a Pakistani HIV-infected individual with virological failure. Genetic analysis of the sequence indicated that this recombinant form is multi-drug resistant, harboring drug resistance mutations against more than one class of antiretroviral drugs.
AB - In Pakistan, the HIV situation has gone from an outbreak to a concentrated epidemic, and the virus has now crossed into the low-risk population. In addition, several new HIV outbreaks have occurred in different parts of the country. HIV-1 subtype A has been the major epidemic subtype in Pakistan; however, as the epidemic has grown, the emergence of several new subtypes and recombinant forms has been observed. Here, we present the first case and genetic analysis of an unassigned, complex recombinant form in a Pakistani HIV-infected individual with virological failure. Genetic analysis of the sequence indicated that this recombinant form is multi-drug resistant, harboring drug resistance mutations against more than one class of antiretroviral drugs.
UR - http://www.scopus.com/inward/record.url?scp=85079704077&partnerID=8YFLogxK
U2 - 10.1007/s00705-020-04551-4
DO - 10.1007/s00705-020-04551-4
M3 - Article
C2 - 32060792
AN - SCOPUS:85079704077
SN - 0304-8608
VL - 165
SP - 967
EP - 972
JO - Archives of Virology
JF - Archives of Virology
IS - 4
ER -
