The inherited deficiency of hepatic UDP-glucuronyltransferase: Structure-activity relationships of in vitro stimulators

El Nasir M.A. Lalani; Philip J. Weatherill; Sue M.E. Kennedy; Brian Burchell

doi:10.1016/0006-2952(80)90271-3

The inherited deficiency of hepatic UDP-glucuronyltransferase: Structure-activity relationships of in vitro stimulators

El Nasir M.A. Lalani
, Philip J. Weatherill
, Sue M.E. Kennedy
, Brian Burchell

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

More than 18 compounds have been tested for their ability to stimulate defective UDP-glucuronyltransferase activity of Gunn rat liver homogenates towards 2-aminophenol, up to levels of transferase activity in similarly treated Wistar rat liver homogenates. The minimum structural requirements of an effective compound are a combination of the presence of an electron-attracting atom or group and a sparing solubility in water. The activation of defective UDP-glucuronyltransferase towards 2-aminophenol by pentan-3-one is reversible. The possible mechanism of action of alkyl ketone activators is discussed.

Original language	English (UK)
Pages (from-to)	2367-2371
Number of pages	5
Journal	Biochemical Pharmacology
Volume	29
Issue number	17
DOIs	https://doi.org/10.1016/0006-2952(80)90271-3
Publication status	Published - 1980
Externally published	Yes

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10.1016/0006-2952(80)90271-3

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title = "The inherited deficiency of hepatic UDP-glucuronyltransferase: Structure-activity relationships of in vitro stimulators",

abstract = "More than 18 compounds have been tested for their ability to stimulate defective UDP-glucuronyltransferase activity of Gunn rat liver homogenates towards 2-aminophenol, up to levels of transferase activity in similarly treated Wistar rat liver homogenates. The minimum structural requirements of an effective compound are a combination of the presence of an electron-attracting atom or group and a sparing solubility in water. The activation of defective UDP-glucuronyltransferase towards 2-aminophenol by pentan-3-one is reversible. The possible mechanism of action of alkyl ketone activators is discussed.",

author = "Lalani, \{El Nasir M.A.\} and Weatherill, \{Philip J.\} and Kennedy, \{Sue M.E.\} and Brian Burchell",

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doi = "10.1016/0006-2952(80)90271-3",

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T1 - The inherited deficiency of hepatic UDP-glucuronyltransferase

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AU - Lalani, El Nasir M.A.

AU - Weatherill, Philip J.

AU - Kennedy, Sue M.E.

AU - Burchell, Brian

PY - 1980

Y1 - 1980

N2 - More than 18 compounds have been tested for their ability to stimulate defective UDP-glucuronyltransferase activity of Gunn rat liver homogenates towards 2-aminophenol, up to levels of transferase activity in similarly treated Wistar rat liver homogenates. The minimum structural requirements of an effective compound are a combination of the presence of an electron-attracting atom or group and a sparing solubility in water. The activation of defective UDP-glucuronyltransferase towards 2-aminophenol by pentan-3-one is reversible. The possible mechanism of action of alkyl ketone activators is discussed.

AB - More than 18 compounds have been tested for their ability to stimulate defective UDP-glucuronyltransferase activity of Gunn rat liver homogenates towards 2-aminophenol, up to levels of transferase activity in similarly treated Wistar rat liver homogenates. The minimum structural requirements of an effective compound are a combination of the presence of an electron-attracting atom or group and a sparing solubility in water. The activation of defective UDP-glucuronyltransferase towards 2-aminophenol by pentan-3-one is reversible. The possible mechanism of action of alkyl ketone activators is discussed.

UR - https://www.scopus.com/pages/publications/0018905885

U2 - 10.1016/0006-2952(80)90271-3

DO - 10.1016/0006-2952(80)90271-3

M3 - Article

C2 - 6775636

AN - SCOPUS:0018905885

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EP - 2371

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 17

ER -

The inherited deficiency of hepatic UDP-glucuronyltransferase: Structure-activity relationships of in vitro stimulators

Abstract

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