The many faces of glioblastoma: Pictorial review of atypical imaging features

Kumail Khandwala, Fatima Mubarak, Khurram Minhas

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Glioblastoma is an aggressive primary central nervous system tumour that usually has a poor prognosis. Generally, the typical imaging features are easily recognisable, but the behaviour of glioblastoma multiforme (GBM) can often be unusual. Several variations and heterogeneity in GBM appearance have been known to occur. In this pictorial essay, we present cases of pathologically confirmed GBM that illustrate unusual locations and atypical features on neuroimaging, and review the relevant literature. Even innocuous-looking foci, cystic lesions, meningeal-based pathology, intraventricular and infra-tentorial masses, multifocal/multicentric lesions and spinal cord abnormalities may represent GBM. We aim to highlight the atypical characteristics of glioblastoma, clarify their importance and list the potential mimickers. Although a definitive diagnosis in these rare cases of GBM warrants histopathological confirmation, an overview of the many imaging aspects may help make an early diagnosis.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalNeuroradiology Journal
Issue number1
Publication statusPublished - Feb 2021


  • CNS tumours
  • Glioblastoma
  • atypical
  • magnetic resonance imaging
  • neuroimaging
  • neuroradiology


Dive into the research topics of 'The many faces of glioblastoma: Pictorial review of atypical imaging features'. Together they form a unique fingerprint.

Cite this