TY - JOUR
T1 - The Pakistan Risk of Myocardial Infarction Study
T2 - A resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia
AU - Saleheen, Danish
AU - Zaidi, Moazzam
AU - Rasheed, Asif
AU - Ahmad, Usman
AU - Hakeem, Abdul
AU - Murtaza, Muhammed
AU - Kayani, Waleed
AU - Faruqui, Azhar
AU - Kundi, Assadullah
AU - Zaman, Khan Shah
AU - Yaqoob, Zia
AU - Cheema, Liaquat Ali
AU - Samad, Abdus
AU - Rasheed, Syed Zahed
AU - Mallick, Nadeem Hayat
AU - Azhar, Muhammad
AU - Jooma, Rashid
AU - Gardezi, Ali Raza
AU - Memon, Nazir
AU - Ghaffar, Abdul
AU - Fazal-Ur-Rehman,
AU - Khan, Nadir
AU - Shah, Nabi
AU - Shah, Asad Ali
AU - Samuel, Maria
AU - Hanif, Farina
AU - Yameen, Madiha
AU - Naz, Sobia
AU - Sultana, Aisha
AU - Nazir, Aisha
AU - Raza, Shehzad
AU - Shazad, Muhammad
AU - Nasim, Sana
AU - Javed, Muhammad Ahsan
AU - Ali, Syed Saadat
AU - Jafree, Mehmood
AU - Nisar, Muhammad Imran
AU - Daood, Muhammad Salman
AU - Hussain, Altaf
AU - Sarwar, Nadeem
AU - Kamal, Ayeesha
AU - Deloukas, Panos
AU - Ishaq, Muhammad
AU - Frossard, Philippe
AU - Danesh, John
N1 - Funding Information:
Funding Epidemiological fieldwork in PROMIS has been supported by unrestricted grants to investigators at the University of Cambridge. The Wellcome Trust has supported a genomewide association scan and other genetic analyses. The British Heart Foundation has supported assays of several candidate biochemical analytes. The Cambridge Commonwealth Society supports Dr. Saleheen. The cardiovascular disease epidemiology group of Professor Danesh is underpinned by programme grants from the British Heart Foundation and the UK Medical Research Council.
PY - 2009/6
Y1 - 2009/6
N2 - The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia than in any other region globally, but there is little direct evidence about its determinants. The Pakistan Risk of Myocardial Infarction Study (PROMIS) is an epidemiological resource to enable reliable study of genetic, lifestyle and other determinants of CHD in South Asia. By March 2009, PROMIS had recruited over 5,000 cases of first-ever confirmed acute myocardial infarction (MI) and over 5,000 matched controls aged 30-80 years. For each participant, information has been recorded on demographic factors, lifestyle, medical and family history, anthropometry, and a 12-lead electrocardiogram. A range of biological samples has been collected and stored, including DNA, plasma, serum and whole blood. During its next stage, the study aims to expand recruitment to achieve a total of about 20,000 cases and about 20,000 controls, and, in subsets of participants, to enrich the resource by collection of monocytes, establishment of lymphoblastoid cell lines, and by resurveying participants. Measurements in progress include profiling of candidate biochemical factors, assay of 45,000 variants in 2,100 candidate genes, and a genomewide association scan of over 650,000 genetic markers. We have established a large epidemiological resource for CHD in South Asia. In parallel with its further expansion and enrichment, the PROMIS resource will be systematically harvested to help identify and evaluate genetic and other determinants of MI in South Asia. Findings from this study should advance scientific understanding and inform regionally appropriate disease prevention and control strategies.
AB - The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia than in any other region globally, but there is little direct evidence about its determinants. The Pakistan Risk of Myocardial Infarction Study (PROMIS) is an epidemiological resource to enable reliable study of genetic, lifestyle and other determinants of CHD in South Asia. By March 2009, PROMIS had recruited over 5,000 cases of first-ever confirmed acute myocardial infarction (MI) and over 5,000 matched controls aged 30-80 years. For each participant, information has been recorded on demographic factors, lifestyle, medical and family history, anthropometry, and a 12-lead electrocardiogram. A range of biological samples has been collected and stored, including DNA, plasma, serum and whole blood. During its next stage, the study aims to expand recruitment to achieve a total of about 20,000 cases and about 20,000 controls, and, in subsets of participants, to enrich the resource by collection of monocytes, establishment of lymphoblastoid cell lines, and by resurveying participants. Measurements in progress include profiling of candidate biochemical factors, assay of 45,000 variants in 2,100 candidate genes, and a genomewide association scan of over 650,000 genetic markers. We have established a large epidemiological resource for CHD in South Asia. In parallel with its further expansion and enrichment, the PROMIS resource will be systematically harvested to help identify and evaluate genetic and other determinants of MI in South Asia. Findings from this study should advance scientific understanding and inform regionally appropriate disease prevention and control strategies.
KW - Case-control study
KW - MI
KW - Myocardial Infarction
KW - Pakistan
KW - Risk factors
KW - South Asia
UR - http://www.scopus.com/inward/record.url?scp=67349163739&partnerID=8YFLogxK
U2 - 10.1007/s10654-009-9334-y
DO - 10.1007/s10654-009-9334-y
M3 - Article
C2 - 19404752
AN - SCOPUS:67349163739
SN - 0393-2990
VL - 24
SP - 329
EP - 338
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 6
ER -