TY - JOUR
T1 - The preterm birth syndrome
T2 - A prototype phenotypic classification
AU - Villar, Jose
AU - Papageorghiou, Aris T.
AU - Knight, Hannah E.
AU - Gravett, Michael G.
AU - Iams, Jay
AU - Waller, Sarah A.
AU - Kramer, Michael
AU - Culhane, Jennifer F.
AU - Barros, Fernando C.
AU - Conde-Agudelo, Agustn
AU - Bhutta, Zulfiqar A.
AU - Goldenberg, Robert L.
N1 - Funding Information:
Supported by the Bill & Melinda Gates Foundation and the Global Alliance to Prevent Prematurity and Stillbirth (an initiative of Seattle Children's), and by INTERGROWTH-21st grant no. 49038 from the Bill & Melinda Gates Foundation to the University of Oxford.
PY - 2012/2
Y1 - 2012/2
N2 - Preterm birth is a syndrome with many causes and phenotypes. We propose a classification that is based on clinical phenotypes that are defined by <1 characteristics of the mother, the fetus, the placenta, the signs of parturition, and the pathway to delivery. Risk factors and mode of delivery are not included. There are 5 components in a preterm birth phenotype: (1) maternal conditions that are present before presentation for delivery, (2) fetal conditions that are present before presentation for delivery, (3) placental pathologic conditions, (4) signs of the initiation of parturition, and (5) the pathway to delivery. This system does not force any preterm birth into a predefined phenotype and allows all relevant conditions to become part of the phenotype. Needed data can be collected from the medical records to classify every preterm birth. The classification system will improve understanding of the cause and improve surveillance across populations.
AB - Preterm birth is a syndrome with many causes and phenotypes. We propose a classification that is based on clinical phenotypes that are defined by <1 characteristics of the mother, the fetus, the placenta, the signs of parturition, and the pathway to delivery. Risk factors and mode of delivery are not included. There are 5 components in a preterm birth phenotype: (1) maternal conditions that are present before presentation for delivery, (2) fetal conditions that are present before presentation for delivery, (3) placental pathologic conditions, (4) signs of the initiation of parturition, and (5) the pathway to delivery. This system does not force any preterm birth into a predefined phenotype and allows all relevant conditions to become part of the phenotype. Needed data can be collected from the medical records to classify every preterm birth. The classification system will improve understanding of the cause and improve surveillance across populations.
KW - phenotype
KW - preterm birth
UR - http://www.scopus.com/inward/record.url?scp=84856397461&partnerID=8YFLogxK
U2 - 10.1016/j.ajog.2011.10.866
DO - 10.1016/j.ajog.2011.10.866
M3 - Article
AN - SCOPUS:84856397461
SN - 0002-9378
VL - 206
SP - 119
EP - 123
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 2
ER -