The preterm birth syndrome: A prototype phenotypic classification

Jose Villar, Aris T. Papageorghiou, Hannah E. Knight, Michael G. Gravett, Jay Iams, Sarah A. Waller, Michael Kramer, Jennifer F. Culhane, Fernando C. Barros, Agustn Conde-Agudelo, Zulfiqar A. Bhutta, Robert L. Goldenberg

Research output: Contribution to journalArticlepeer-review

186 Citations (Scopus)

Abstract

Preterm birth is a syndrome with many causes and phenotypes. We propose a classification that is based on clinical phenotypes that are defined by <1 characteristics of the mother, the fetus, the placenta, the signs of parturition, and the pathway to delivery. Risk factors and mode of delivery are not included. There are 5 components in a preterm birth phenotype: (1) maternal conditions that are present before presentation for delivery, (2) fetal conditions that are present before presentation for delivery, (3) placental pathologic conditions, (4) signs of the initiation of parturition, and (5) the pathway to delivery. This system does not force any preterm birth into a predefined phenotype and allows all relevant conditions to become part of the phenotype. Needed data can be collected from the medical records to classify every preterm birth. The classification system will improve understanding of the cause and improve surveillance across populations.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume206
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • phenotype
  • preterm birth

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